Prehabilitation for Cancer Surgery

This trial tests a program called Comprehensive Multimodal Prehabilitation (CMMP) to determine its effectiveness in helping individuals who are frail or nearly frail and have certain cancers—such as pancreatic, ovarian, kidney, or bladder cancer—prepare for major surgery. The trial examines whether the program alone or combined with other pre-surgery treatments (neoadjuvant therapy) can improve surgical outcomes. The program includes nutrition counseling, exercise, and breathing exercises to enhance patients' strength and readiness for surgery. Candidates for this trial include those diagnosed with one of these cancers, considered frail, and able to manage the program's exercises and dietary changes. As a Phase 2 trial, this research measures the treatment's effectiveness in an initial, smaller group, providing an opportunity to contribute to significant findings.

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor to get specific guidance based on your situation.

Research has shown that comprehensive multimodal prehabilitation (CMMP) is generally safe for patients. Studies have found that it can reduce the risk of complications after surgeries, such as those for lung and colorectal cancer. Specifically, patients who used CMMP experienced fewer issues in the 30 days following lung cancer surgery.

Most treatments for cancer focus on surgery, chemotherapy, or radiation after diagnosis. However, the Comprehensive Multimodal Prehabilitation (CMMP) approach is unique because it prepares patients before major cancer surgery. This method combines motivational interviewing, nutritional counseling with protein supplements, inspiratory muscle training, and physical exercises like aerobic and strength training. Researchers are excited because this proactive strategy aims to boost patients’ physical and mental readiness, potentially improving recovery and outcomes post-surgery. By targeting patients' overall health before surgery, CMMP may offer a valuable new angle in cancer care.

This trial will evaluate the effectiveness of Comprehensive Multimodal Prehabilitation (CMMP) for patients undergoing major cancer surgery. Studies have shown that preparing for surgery with a combination of exercises and nutrition support can enhance recovery. Research indicates this approach reduces complications and improves physical function after surgery, particularly for cancers like lung and colorectal cancer. It has also been found to lower anxiety levels in patients. However, its effectiveness can vary depending on the type of surgery and the patient group. Overall, it appears to be a promising method for preparing for major cancer surgeries. Participants in this trial will receive the CMMP intervention, with some also receiving planned neoadjuvant therapy.¹²⁴⁵⁶