Zanubrutinib + Sonrotoclax for CLL/SLL
What You Need to Know Before You Apply
What is the purpose of this trial?
This phase II trial tests how well giving zanubrutinib and sonrotoclax works for the treatment of chronic lymphocytic leukemia (CLL)/small lymphocytic leukemia (SLL) that has come back after a period of improvement (relapsed). Zanubrutinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Sonrotoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) and BCL-XL inhibitors. It may stop the growth of tumor cells and may kill them by blocking Bcl-2 and Bcl-XL, proteins needed for cell survival. Giving zanubrutinib and sonrotoclax may work well for the treatment of relapsed CLL/SLL.
Who Is on the Research Team?
Tanya Siddiqi
Principal Investigator
City of Hope Medical Center
Are You a Good Fit for This Trial?
This trial is for adults with chronic lymphocytic leukemia (CLL) or small lymphocytic leukemia (SLL) whose disease has come back after previous treatment. Participants should be healthy enough for study procedures and meet specific medical requirements set by the researchers.Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- Sonrotoclax
- Zanubrutinib
Trial Overview
The study is testing a combination of two drugs, zanubrutinib and sonrotoclax, to see how well they work together in treating relapsed CLL/SLL. The trial includes regular scans, blood tests, and biopsies to monitor progress.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
CYCLE 1-4: Patients receive zanubrutinib PO QD on days 1-28 of each cycle. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. CYCLE 5+: Patients receive zanubrutinib PO QD and sonrotoclax PO QD on days 1-28 of each cycle. Cycles repeat every 28 days for up to 24 cycles in the absence of disease progression or unacceptable toxicity. Patients undergo bone marrow biopsy and aspiration, CT scan/MRI and blood sample collection throughout the study. Patients may undergo lymph node biopsy during screening and optionally at time of progression.
Find a Clinic Near You
Who Is Running the Clinical Trial?
City of Hope Medical Center
Lead Sponsor
National Cancer Institute (NCI)
Collaborator
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