Biocidin REMOVE for IBS

GD
LD
Overseen ByLisa Datta
Prior Safety DataThis treatment has passed at least one previous human trial

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests whether an herbal supplement called Biocidin REMOVE can help clear small intestinal bacterial overgrowth (SIBO) in adults with irritable bowel syndrome (IBS). SIBO occurs when excessive bacteria in the small intestine worsen IBS symptoms. The study will compare Biocidin REMOVE to a placebo to determine if it reduces IBS symptoms and improves quality of life. Adults with IBS who have tested positive for SIBO might be suitable candidates, especially if they frequently experience gut issues. Participants will take capsules and undergo tests to assess their SIBO and gut health over several weeks. As a Phase 2 trial, this research focuses on evaluating the treatment's effectiveness in an initial, smaller group, offering participants a chance to contribute to important findings on IBS management.

Is there any evidence suggesting that Biocidin REMOVE is likely to be safe for humans?

Research has shown that Biocidin REMOVE is generally suitable for individuals seeking to improve gut health. This herbal supplement may assist with small intestinal bacterial overgrowth (SIBO), which can exacerbate irritable bowel syndrome (IBS) symptoms. However, limited information exists on its safety for humans specifically for this use.

In this trial phase, researchers primarily assess the safety of Biocidin REMOVE and its tolerability. They monitor for any side effects or adverse reactions. As this is an early stage of the trial, while some initial safety data might be available, further research is necessary to fully understand its safety profile.

This trial is a crucial step in determining the safety of Biocidin REMOVE for treating SIBO and IBS. Participants play a vital role in helping researchers gather the necessary information to evaluate its safety and effectiveness.12345

Why do researchers think this study treatment might be promising?

Unlike the standard treatments for IBS, which often include dietary changes, fiber supplements, antispasmodics, and probiotics, Biocidin REMOVE is a unique herbal preparation. It contains a proprietary blend of botanical ingredients, which may offer a new mechanism of action by targeting the gut microbiome differently than conventional treatments. Researchers are excited about its potential to provide relief in a natural form, with a structured dosing regimen that starts with a gradual increase. This could make it a promising alternative for those seeking more natural treatment options for IBS.

What evidence suggests that Biocidin REMOVE might be an effective treatment for IBS?

Research has shown that Biocidin REMOVE, which participants in this trial may receive, may help reduce bacteria in the small intestine for adults with irritable bowel syndrome (IBS). It is particularly effective for certain types of bacterial overgrowth, improving breath test results. This reduction in bacteria can alleviate IBS symptoms such as bloating, gas, and cramping. Biocidin breaks down protective layers formed by bacteria, allowing the body to eliminate unwanted bacteria and restore gut balance.12367

Who Is on the Research Team?

GM

Gerry Mullin, MD

Principal Investigator

Johns Hopkins University

Are You a Good Fit for This Trial?

This trial is for adults age 18 or older who have irritable bowel syndrome (IBS) and small intestinal bacterial overgrowth (SIBO).

Inclusion Criteria

I agree to use a highly effective birth control method during the study.
I am 18 years old or older.
I have IBS and my breath test showed very low gas levels with no spikes.
See 1 more

Exclusion Criteria

I have chronic liver disease or abnormal liver test results in the past 6 months.
Negative SIBO breath testing at baseline
Untreated significant anxiety or depression
See 13 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

Up to 30 days

Titration

Participants undergo a 9-day titration period to gradually increase the dose of Biocidin REMOVE or placebo

9 days
1 visit (in-person)

Treatment

Participants take the target dose of two capsules twice daily for 28 days

4 weeks
2 visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment, including a check-in visit and assessments

4 weeks
1 visit (in-person)

What Are the Treatments Tested in This Trial?

Interventions

  • Biocidin REMOVE

Trial Overview

The study tests whether an herbal supplement called Biocidin REMOVE can reduce SIBO and improve IBS symptoms compared to a placebo. Participants take capsules twice daily for about 5 weeks, with neither they nor the researchers knowing which treatment they're getting.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Placebo Group

Group I: Biocidin REMOVEExperimental Treatment1 Intervention
Group II: PlaceboPlacebo Group1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Johns Hopkins University

Lead Sponsor

Trials
2,366
Recruited
15,160,000+

Biocidin

Collaborator

Trials
1
Recruited
40+

Citations

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