Alirocumab for High Cholesterol
(ASCEND-QW Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This study is researching an experimental drug called alirocumab, referred to as "study drug". In the United States, alirocumab is approved for the treatment of hypercholesterolemia (high blood cholesterol levels).
The aim of the study is to see how safe and effective alirocumab is when given weekly to adult participants who have hypercholesterolemia.
The study is looking at several other research questions, including:
* What side effects may happen from taking the study drug once a week
* How much study drug is in the blood at different times
Who Is on the Research Team?
Clinical Trial Management
Principal Investigator
Regeneron Pharmaceuticals
Are You a Good Fit for This Trial?
This trial is for adults with high cholesterol (specifically, elevated LDL-C levels). Participants should not have conditions or factors that would make it unsafe to join, as detailed in the study protocol.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive weekly doses of alirocumab to evaluate its safety and efficacy
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Trial Overview
The study is testing how safe and effective a drug called alirocumab is when given once a week to people with high cholesterol. Researchers will also measure drug levels in the blood and monitor for side effects.
How Is the Trial Designed?
4
Treatment groups
Experimental Treatment
Find a Clinic Near You
Who Is Running the Clinical Trial?
Regeneron Pharmaceuticals
Lead Sponsor
Leonard Schleifer
Regeneron Pharmaceuticals
Chief Executive Officer since 1988
MD and PhD in Medicine
George Yancopoulos
Regeneron Pharmaceuticals
Chief Medical Officer since 1997
MD from Harvard Medical School
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