DBS Surgery for Hand Dystonia

This trial tests a procedure called deep brain stimulation (DBS) to assist individuals with severe focal hand dystonia, a condition causing involuntary hand movements. The treatment places a device in the chest connected to wires in the brain to block the nerve signals causing these movements. Researchers aim to gain insights into brain and nerve cell function in those with dystonia. Individuals with severe hand dystonia who have tried botulinum toxin treatment at least twice may be suitable candidates for this trial. As a Phase 1 and Phase 2 trial, the study focuses on understanding how the treatment works in people and measuring its effectiveness in an initial, smaller group.

The trial information does not specify if you need to stop taking your current medications. However, if you are on anticoagulation therapy (blood thinners), you may not be able to participate in the trial.

Research has shown that deep brain stimulation (DBS) is generally safe for treating dystonia, a movement disorder. Studies have found that DBS can improve symptoms and enhance the quality of life for people with various types of dystonia. These studies also report that DBS is well-tolerated and has maintained a good safety record over many years.

Deep Brain Stimulation (DBS) surgery is unique because it offers a targeted approach to treating hand dystonia, a condition often managed with medications like botulinum toxin injections or oral drugs that can have systemic effects. Unlike these treatments, DBS involves implanting electrodes in specific areas of the brain to modulate abnormal nerve signals, which could provide more precise symptom control with potentially fewer side effects. Researchers are excited about DBS because it has shown promise in other movement disorders, like Parkinson's disease, suggesting it might offer significant relief for hand dystonia patients who have not responded well to conventional therapies.

Research has shown that deep brain stimulation (DBS) effectively treats various types of dystonia, including focal hand dystonia (FHD). One study found that DBS improved movement and quality of life for people with dystonia. Another analysis confirmed that DBS is safe and significantly reduces symptoms. This procedure involves placing a small device in the chest, connected to wires in the brain, to help block abnormal nerve signals. Early findings suggest that DBS can lessen the severity of involuntary movements in people with FHD. Participants in this trial will undergo DBS surgery to evaluate its effectiveness specifically for hand dystonia.¹²⁶⁷⁸