Ketorolac + Lidocaine for Pain Management

(PCB-KinD Trial)

This trial aims to improve pain management for those needing osmotic dilators before a second-trimester abortion. It will test a mix of ketorolac (an anti-inflammatory similar to ibuprofen) and lidocaine (a numbing medicine) injected around the cervix. The trial includes two groups: one receiving the new injection and a placebo pill, and the other receiving standard treatment with ibuprofen and lidocaine. Candidates may be suitable if they seek an outpatient abortion at Rush University Medical Center and require osmotic dilators placed the day before the procedure.

As a Phase 2 trial, this research focuses on measuring the treatment's effectiveness in an initial, smaller group of people, offering participants a chance to contribute to advancing pain management options.

The trial requires that you have not taken NSAIDs (like ibuprofen) less than 6 hours before your clinic visit. If you are currently using narcotics or recreational drugs (except cannabis), you may not be eligible to participate.

Research has shown that using ketorolac and lidocaine together is generally safe and effective for pain relief. In studies, patients who received this combination reported significantly lower pain levels compared to those who only received lidocaine. This suggests that the combination is both effective and safe.

Researchers are excited about the combination of Ketorolac and Lidocaine for pain management because it offers a novel approach to blocking pain. Unlike standard treatments like ibuprofen with lidocaine, this combination uses Ketorolac, a non-steroidal anti-inflammatory drug (NSAID), to potentially enhance pain relief when used with Lidocaine. This method could provide more effective pain management without relying solely on oral medications, promising quicker and potentially stronger relief.

Research has shown that combining ketorolac with lidocaine for pain relief is more effective than using lidocaine alone. In this trial, participants in the intervention treatment group will receive a paracervical block with a combination of 1% lidocaine and ketorolac. Studies have found that this combination significantly reduces pain within the first 24 hours after procedures. Specifically, patients who received both ketorolac and lidocaine reported less pain compared to those who only received lidocaine. This combination not only alleviates immediate pain but also enhances comfort during recovery. These findings suggest that using ketorolac with lidocaine could be a promising approach to managing pain from osmotic dilator insertion.²³⁶⁷⁸