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Verapamil for Cystic Fibrosis and Diabetes

Not yet recruiting at 1 trial location
KJ
Overseen ByKevin J Scully
Age: Any Age
Sex: Any
Trial Phase: Phase 2
Sponsor: Rhode Island Hospital
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Prior Safety DataThis treatment has passed at least one previous human trial

What You Need to Know Before You Apply

What is the purpose of this trial?

The investigators are conducting a pilot open-label pre/post interventional trial in adolescents and adults with cystic fibrosis (CF) and abnormal glucose tolerance or early CF-related diabetes mellitus (CFRD) to assess the safety and efficacy of verapamil on beta cell function and dysglycemia.

Are You a Good Fit for This Trial?

This trial is for teens and adults with cystic fibrosis who have abnormal blood sugar levels or early-stage diabetes related to CF. Participants should not have other major health issues that would prevent safe participation.

Inclusion Criteria

AGT defined as OGTT 2-hour glucose >140 mg/dL and <200 mg/dL or OGTT 1-hour glucose >200 mg/dL
I have a confirmed genetic diagnosis of cystic fibrosis.
CFRD defined as fasting glucose >126 mg/dL and/or OGTT 2-hour glucose >200 mg/dL
See 5 more

Exclusion Criteria

I need to take certain medications like beta blockers or lithium.
Allergy to any components of the MMTT standardized meal
My liver tests are high or I have severe liver disease.
See 19 more

What Are the Treatments Tested in This Trial?

Interventions

  • Verapamil Hydrochloride

Trial Overview

The study tests whether verapamil, a medication usually used for heart conditions, can help improve insulin-producing cell function and blood sugar control in people with CF-related high blood sugar. All participants receive the drug and are monitored before and after treatment.

How Is the Trial Designed?

1

Treatment groups

Experimental Treatment

Group I: Intervention ArmExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Rhode Island Hospital

Lead Sponsor

Trials
275
Recruited
71,400+

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