PNMR for Post-COVID Syndrome
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores a new treatment option for individuals dealing with Long COVID, a condition where symptoms persist or emerge months after the initial infection. Participants will receive either a new treatment called Paragon Novel Metabolic Regulator (PNMR) along with standard care or just standard care for six weeks. The researchers aim to determine if PNMR can manage Long COVID symptoms more effectively than standard care alone. Individuals with a confirmed COVID-19 diagnosis who continue to experience symptoms three months after infection might be suitable candidates. As a Phase 2 trial, this research measures the treatment's effectiveness in an initial, smaller group, offering a chance to contribute to important findings.
Will I have to stop taking my current medications?
Yes, you will need to stop taking any over-the-counter supplements, vitamins, or natural products, as well as any medications that could affect fatigue and cognitive function during the study.
Is there any evidence suggesting that this trial's treatments are likely to be safe?
Earlier studies indicate that patients using Paragon Novel Metabolic Regulator (PNMR) have generally tolerated the treatment well, with few reports of side effects. Some individuals have experienced gas with a sulfur-like smell, signaling the body's adjustment to the treatment. Rarely, patients have reported unpleasant dreams, which may suggest a need for a lower dosage. This trial is in a phase that evaluates both safety and effectiveness, and earlier research suggested that PNMR is safe. However, as the treatment remains under investigation, researchers continue to learn about its safety for everyone.12345
Why do researchers think this study treatment might be promising for Long COVID?
The Paragon Novel Metabolic Regulator (PNMR) is unique because it targets post-COVID syndrome by focusing on the body's metabolic processes, specifically replenishing depleted sulfur protein nutrient stores essential for energy production and healing. Unlike standard treatments that typically manage symptoms with medications like corticosteroids or breathing exercises, PNMR potentially accelerates recovery by adjusting dosage based on individual healing signals, such as sulfur-smelling flatulence, which indicates the body's need for the active ingredient is decreasing. Researchers are excited about this treatment because it offers a personalized approach, allowing patients to tailor their dosage based on their body's signals, which could lead to more efficient and effective recovery from long COVID symptoms.
What evidence suggests that PNMR could be an effective treatment for Long COVID?
Research has shown that conditions like Long COVID link to changes in how the body uses energy and manages inflammation. Studies have found that these conditions cause noticeable shifts in these processes. In this trial, one group of participants will receive the Paragon Novel Metabolic Regulator (PNMR) along with dietary and lifestyle recommendations and standard care. Early results suggest that addressing these issues can improve symptoms for people with Long COVID, making PNMR a promising option for managing the condition.16789
Who Is on the Research Team?
Sam Bock, BA Environmental Science
Principal Investigator
ParagonClinicals Inc CEO / CSO
Are You a Good Fit for This Trial?
This trial is for adults experiencing long COVID symptoms, such as mental fatigue, after recovering from COVID-19. Healthy volunteers may also participate. People with other serious health conditions or who do not meet the study requirements cannot join.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive PNMR + SOC or SOC alone for 6 weeks, with dietary and lifestyle recommendations
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Paragon Novel Metabolic Regulator (PNMR)
Trial Overview
The study compares a new treatment called Paragon Novel Metabolic Regulator (PNMR) plus standard care to standard care alone over six weeks. All participants receive dietary and lifestyle advice aimed at boosting immune function.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Patients in Group 2 will be given specific dietary and lifestyle recommendations. Patients receiving PNMR will additionally be treated with SOC as per the regional guidelines and the decision of the treating physician.
Patients in Group 1 are instructed to take 2 PNMR packs on Day 1 and evaluate and adjust their daily PNMR dosage from Day 2 to Day 42 of their 6-week treatment period up to a maximum of 6 packs per day based on the presence of long COVID symptoms. Patients lower the dosage by 1 pack /day based upon signals showing the body is healing (and has replenished its depleted sulfur protein nutrient stores - required for energy production and healing), as seen with a temporary release of sulfur-smelling flatulence, or rarely unpleasant dreams, if the patient no longer needs as much medicine. Patients maintain a minimum dosage of no less than 1 pack per 2 days. Patients are instructed to take PNMR 5-20 minutes before eating, 3-6 capsules at a time, with water. Patients in Group 1 are also given specific dietary and lifestyle recommendations. Patients receiving PNMR will additionally be treated with SOC as per the regional guidelines and the decision of the treating physician.
Find a Clinic Near You
Who Is Running the Clinical Trial?
ParagonClinicals Inc.
Lead Sponsor
Citations
Evaluating the Safety and Efficacy of PNMR as Treatment ...
Patients will be treated with Paragon Novel Metabolic Regulator (PNMR) + standard of care (SOC) or SOC alone for 6 weeks for the treatment of ...
The Impact of Metabolic Syndrome on the Outcomes of ... - PMC
Substantial evidence supports the effectiveness of post-COVID-19 rehabilitation in enhancing physical performance, muscle strength, coordination, and mental ...
3.
omfcanada.ngo
omfcanada.ngo/systems-modeling-reveals-shared-metabolic-dysregulation-and-novel-therapeutic-treatments-in-me-cfs-and-long-covid/Systems Modeling Reveals Shared Metabolic ...
In a recently released preprint, OMF's computation team investigated the shared metabolic symptoms found in ME/CFS and Long COVID.
Metabolic signatures of post-viral syndromes: insights from ...
Together, these studies demonstrate that chronic post-viral syndromes are underpinned by measurable metabolic and inflammatory alterations, ...
Pycnogenol® in Post-COVID-19 Condition
Pycnogenol® may have potential to improve the health status of people suffering from post COVID-19 condition. This trial lasts for 12 weeks.
Long-COVID, Metabolic and Endocrine Disease - PMC
Initial studies have shown that people with overweight and diabetes mellitus have a higher risk of developing long-COVID associated symptoms.
Novel Clinical, Immunological, and Metabolic Features ...
This study investigates clinical, immunological, and metabolomic risk factors associated with post-acute COVID-19 syndrome (PACS) in 51 patients.
COVID-19 Research Literature - LibGuides
Clinical Trials (see more at the U.S. National Library of Medicine) · Evaluating the Safety and Efficacy of PNMR as Treatment for Long COVIDThis ...
9.
frontiersin.org
frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2024.1429281/fullExploring metabolic anomalies in COVID-19 and post- ...
This study employs a novel approach utilizing machine learning (ML) and explainable artificial intelligence (XAI) to analyze metabolic alterations in COVID-19 ...
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