Contact Lens Wear for Fuchs' Dystrophy

This trial explores how wearing contact lenses affects the eyes of people with Fuchs' Dystrophy compared to those with healthy eyes. Researchers aim to determine if corneal swelling (thickness changes) differs after wearing the lenses for a few hours. Participants with Fuchs' Dystrophy must have a diagnosis and plan for a corneal transplant soon, while those with healthy eyes should have no history of eye diseases or surgeries. As a Phase 1 and Phase 2 trial, this research focuses on understanding how the lenses work in people and measuring their effectiveness in an initial, smaller group, offering participants a chance to contribute to groundbreaking eye health research.

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

Research has shown that wearing contact lenses is usually safe for individuals with eye conditions, including Fuchs' Dystrophy. Studies have found that both soft and hard contact lenses can be worn safely for extended periods. For example, a study involving 50 firefighters who wore contact lenses for up to 10 months reported no major issues.

For those with Fuchs' Dystrophy, using special contact lenses with saline solution has reduced symptoms like eye swelling. These lenses were comfortable for most users, causing no significant discomfort or side effects.

Unlike the standard treatments for Fuchs' Dystrophy, such as corneal transplants or endothelial keratoplasty, this approach involves wearing a contact lens. Researchers are excited about this method because it offers a non-invasive way to potentially manage symptoms. The use of contact lenses could provide immediate relief and improve vision without surgery. This approach could simplify the management of Fuchs’ Dystrophy, making it accessible and convenient for more patients.

This trial will compare the effects of wearing contact lenses in individuals with Fuchs' Endothelial Dystrophy (FECD) to those with healthy eyes. Research has shown that contact lenses might alleviate FECD symptoms. One report found that a special soft contact lens, used with a saline solution, reduced eye swelling, a common issue in FECD. Another study with firefighters found that both soft and hard contact lenses are safe for long-term use. Participants in these studies reported fewer symptoms, suggesting that contact lenses might help manage FECD. Overall, wearing contact lenses appears promising for reducing FECD symptoms.¹²⁴⁵⁶