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Tovecimig + FOLFIRI for Colorectal Cancer

OA
Overseen ByOlivia Aranha, MD, PhD
Age: 18+
Sex: Any
Trial Phase: Phase 2
Sponsor: Washington University School of Medicine
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Prior Safety DataThis treatment has passed at least one previous human trial

What You Need to Know Before You Apply

What is the purpose of this trial?

This is an open-label Phase 2 study to evaluate the safety and efficacy of Tovecimig combined with FOLFIRI in patients who have received one prior line of therapy for advanced or metastatic colorectal cancer (CRC).

Who Is on the Research Team?

OA

Olivia Aranha, MD, PhD

Principal Investigator

Washington University School of Medicine

Are You a Good Fit for This Trial?

This trial is for adults with advanced or metastatic colorectal cancer who have already tried one previous treatment. Participants should be healthy enough for more therapy and meet specific health requirements set by the study.

Inclusion Criteria

I have had my main tumor surgically removed.
I agree to use effective birth control during and after the study.
I understand the study and am willing to sign the consent form.
See 6 more

Exclusion Criteria

My cancer is MSI-H positive.
I am HIV positive and have had an undetectable viral load for at least 6 months on treatment.
Pregnant or breastfeeding; women of childbearing potential must have negative pregnancy test within 14 days of C1D1
See 16 more

What Are the Treatments Tested in This Trial?

Interventions

  • 5-Fluorouracil (5-FU)
  • Irinotecan
  • Leucovorin
  • Tovecimig

Trial Overview

The study tests a new drug, Tovecimig, given together with standard chemotherapy drugs (FOLFIRI: leucovorin, irinotecan, and 5-fluorouracil) to see if this combination works better as a second-line treatment. All participants know which treatments they receive.

How Is the Trial Designed?

1

Treatment groups

Experimental Treatment

Group I: Tovecimig and Irinotecan + Leucovorin + 5-Fluorouracil (FOLFIRI regimen)Experimental Treatment4 Interventions

Find a Clinic Near You

Who Is Running the Clinical Trial?

Washington University School of Medicine

Lead Sponsor

Trials
2,027
Recruited
2,353,000+

Compass Therapeutics

Industry Sponsor

Trials
5
Recruited
430+

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