STX-003 + Pembrolizumab for Advanced Solid Tumors
What You Need to Know Before You Apply
What is the purpose of this trial?
Phase 1/2, Open-label, Multi-center, First-in-human Study of the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Anti-tumor Activity of STX-003 Delivered by Intravenous Injection in Patients with Advanced Solid Tumors as a Monotherapy or in Combination with Pembrolizumab.
Are You a Good Fit for This Trial?
This trial is for adults with advanced solid tumors, such as non-small cell lung cancer or melanoma, whose cancer has not responded to standard treatments. Participants should be in generally stable health and able to undergo regular clinic visits.Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- KEYTRUDA®
- STX-003
Trial Overview
Researchers are testing a new drug called STX-003 given by IV, either alone or together with pembrolizumab (KEYTRUDA). The study aims to find the safest dose and see how well these treatments work against advanced cancers.
How Is the Trial Designed?
4
Treatment groups
Experimental Treatment
STX-003 administered intravenously, at 4 planned dose expansion cohorts in patients with advanced cancers with high unmet need, once per cycle for up to 35 cycles (approximately 24 months).
STX-003 administered intravenously, at 4 planned dose expansion cohorts in patients with advanced cancers with high unmet need, once per cycle for up to 35 cycles (approximately 24 months).
STX-003 administered intravenously, at ascending doses across sequential cohorts, once per cycle for up to 35 cycles (approximately 24 months).
STX-003 administered intravenously, at ascending doses across sequential cohorts, once per cycle in combination with pembrolizumab for up to 35 cycles (approximately 24 months).
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Who Is Running the Clinical Trial?
Strand Therapeutics Inc.
Lead Sponsor
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