tDCS for Expressive Aphasia

(STARS Trial)

This trial explores whether adding transcranial Direct Current Stimulation (tDCS), a non-invasive brain stimulation technique, can enhance language recovery in individuals with Broca's aphasia, which impairs speech after a stroke. The study compares two different tDCS intensities and a placebo version to determine the most effective option alongside traditional speech therapy. It targets those who experienced a stroke over six months ago and have Broca's aphasia, affecting their speech and language comprehension. Participants must have used English as their primary language for over 15 years.

As a Phase 2, Phase 3 trial, this research measures the treatment's effectiveness in an initial, smaller group and represents the final step before FDA approval. It offers participants a chance to contribute to potentially groundbreaking advancements in stroke recovery therapies.

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the study team or your doctor.

Research has shown that transcranial Direct Current Stimulation (tDCS) is generally safe. This non-invasive treatment uses gentle electrical currents to stimulate the brain and is usually well-tolerated. Specifically, tDCS has been safely used to improve language skills in people with aphasia.

Studies suggest that 1 mA and 2 mA tDCS treatments are painless and have only minor side effects when used properly. These side effects might include slight tingling or skin redness, which are usually temporary. Both levels of stimulation have shown promise in enhancing language recovery when combined with speech therapy.

Researchers are excited about transcranial Direct Current Stimulation (tDCS) for expressive aphasia because it offers a unique, non-invasive approach to enhancing language recovery. Unlike traditional speech therapy, which relies solely on behavioral techniques, tDCS involves applying a mild electrical current to specific brain regions to potentially boost neural activity and connectivity. This method could complement existing therapies by directly targeting the brain's language centers, potentially accelerating recovery and improving outcomes for patients struggling with speech production.

This trial will compare different approaches to using transcranial Direct Current Stimulation (tDCS) for expressive aphasia. Studies have shown that combining tDCS with speech therapy can significantly enhance language skills in individuals with aphasia, a condition affecting speaking and understanding language. One study reported a 32.6% improvement in speaking, understanding, and reading when tDCS was added to therapy. This suggests that tDCS may enhance the effectiveness of traditional speech therapy. However, some research indicates that not everyone fully recovers, and some language difficulties may persist. Overall, the results are promising and suggest that tDCS could be a valuable addition for helping individuals with aphasia regain language skills.²⁴⁶⁷⁸