Exercise and Cognitive Rehabilitation for Cancer Survivors

(ECO 2 Trial)

This trial aims to evaluate how different approaches can assist cancer survivors with memory and thinking issues after treatment. Participants will be divided into groups to test the effects of exercise, cognitive training (ECO), and a combination of both, compared to standard care. Eligible participants must have had cancer, completed primary treatments, and have concerns about memory or thinking abilities. As an unphased trial, this study provides a unique opportunity to explore innovative strategies for enhancing cognitive health post-cancer treatment.

The trial does not specify if you need to stop taking your current medications, but it does allow patients on endocrine therapies to enroll. It's best to discuss your specific medications with the trial team.

Previous studies have generally found exercise programs like EXCAP to be safe for cancer survivors. Research shows that exercise can improve health and help manage side effects. Survivors often benefit from exercise plans tailored to their needs.

Specific safety data for MAAT is limited, but similar therapies have been well-received. MAAT aims to enhance memory and attention through brain training, which has shown promise in helping cancer survivors think more clearly.

The ECO program combines exercise and brain training. Exercise is linked to better overall health and reduced cancer-related fatigue. While detailed safety data on ECO isn't available, exercise and brain training are generally safe and well-tolerated for cancer survivors.

Researchers are excited about the Exercise and Cognitive Rehabilitation treatments because they offer a fresh approach to helping cancer survivors. Unlike standard care, which often focuses on medication and traditional therapies, these treatments integrate physical exercise and cognitive training. The EXCAP program is unique because it combines home-based walking and resistance exercises with digital health tools to monitor progress and tackle barriers. Meanwhile, the MAAT intervention uses cognitive behavioral therapy principles to improve memory and attention, teaching stress management and coping skills. Together, these treatments aim to enhance both physical and cognitive health, offering a comprehensive way to improve the overall well-being of cancer survivors.

Research shows that exercise can enhance thinking and memory in cancer survivors. Studies indicate that exercise improves brain function test results and boosts self-reported mental abilities. In this trial, participants may join the EXCAP program, which has demonstrated benefits like improved quality of life and reduced fatigue. Meanwhile, some participants will receive MAAT, which effectively aids cancer survivors with memory and attention issues. Others will participate in the ECO program, which combines exercise with brain training and has shown promise in enhancing mental function and overall well-being. These findings suggest that these activities could improve thinking and memory for cancer survivors.⁶⁷⁸⁹¹⁰