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20 Participants NeededMy employer runs this trial

Ear Nerve Stimulation for Uveitis

Recruiting at 6 trial locations
JF
DK
Overseen ByDaniel Kowalsky Moskaliuk, OD
Age: 18+
Sex: Any
Trial Phase: Phase 1
Sponsor: Memorial Sloan Kettering Cancer Center
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

The purpose of this study to find out whether a device that delivers mild electrical stimulation to the ear (transcutaneous auricular vagus nerve stimulation, or taVNS) can reduce inflammation in the eye in people with ocular inflammatory conditions. The device is called the Cymbathera One System.

Who Is on the Research Team?

JF

Jasmine Francis, MD

Principal Investigator

Memorial Sloan Kettering Cancer Center

Are You a Good Fit for This Trial?

This trial is for people with eye inflammation (uveitis) or complications from an artificial lens in the eye. Specific inclusion and exclusion criteria are not listed, but participants should have these conditions.

Inclusion Criteria

Able to attend all study visits at approximately the same time of day (within a 3-hour window)
I have eye inflammation with fluid in or under the retina, or both eyes have surface inflammation.
I have either my natural eye lens or an artificial lens in my eye.
See 3 more

Exclusion Criteria

Untreated or poorly controlled psychiatric illness
Presence of chronically implanted electronic medical device including pacemakers, defibrillators, cochlear implants, spinal stimulators, and vagus nerve stimulators
Substance abuse problem including alcoholism
See 17 more

What Are the Treatments Tested in This Trial?

Interventions

  • Cymbathera One System

Trial Overview

The study tests whether a device called Cymbathera One System, which gives gentle electrical stimulation to the ear, can help reduce inflammation inside the eye.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Group I: Intra/subretinal fluid groupExperimental Treatment1 Intervention
Group II: Inflammatory Ocular Surface GroupExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Memorial Sloan Kettering Cancer Center

Lead Sponsor

Trials
1,998
Recruited
602,000+

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