Disulfiram for Brain Tumor

TH
Overseen ByTiffany Hodges, MD
Age: 18+
Sex: Any
Trial Phase: Phase 1
Sponsor: Case Comprehensive Cancer Center
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This research study is for participants with glioblastoma. It can cause a tumor immunosuppression which helps myeloid cells that can stop T-cell function. Disulfiram is a drug that has been used in treating other disorders, but this study will examine if disulfiram can help make the tumor environment less immunosuppressive and reduce brain swelling when taken before surgery.

Who Is on the Research Team?

TH

Tiffany Hodges, MD

Principal Investigator

University Hospitals Cleveland Medical Center

Are You a Good Fit for This Trial?

Inclusion Criteria

I have a high-grade brain tumor and am scheduled for surgery.
I am 18 years old or older.
My recent blood and liver tests show my organs are working well enough for treatment.
See 5 more

Exclusion Criteria

Subjects receiving any other investigational agents
Known hypersensitivity to disulfiram or thiuram derivatives
I have taken steroids like dexamethasone for brain swelling before joining the study.
See 7 more

What Are the Treatments Tested in This Trial?

How Is the Trial Designed?

1

Treatment groups

Experimental Treatment

Group I: DisulfiramExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Case Comprehensive Cancer Center

Lead Sponsor

Trials
472
Recruited
33,400+