5-fluorouracil + Aluminum for Actinic Keratosis

This trial explores a new treatment for actinic keratosis (AK), which are rough, scaly patches that can develop into skin cancer. Researchers are testing whether adding Aluminum Chloride Hexahydrate to a common cream for AK, 5-fluorouracil (5-FU), can enhance its effectiveness. Participants will apply two different creams to AKs on either their scalp or forearms to determine which is more effective. Individuals with 4-15 AKs on their scalp or forearms, and no other skin cancers or open wounds in the treatment area, might be suitable candidates. As a Phase 1 trial, the research focuses on understanding how the treatment works in people, offering participants a chance to be among the first to receive this potentially groundbreaking treatment.

Yes, you will need to stop using certain medications, such as prescription topical drugs, immunomodulatory or immunosuppressive medicines, chemotherapy, and vitamin A derivatives, at least one month before joining the trial.

Research has shown that 5-fluorouracil (5-FU) is generally safe and effective for treating actinic keratosis (AK), which are skin spots that could become cancerous. Studies have found that some people may experience skin reactions like redness and irritation while using 5-FU. These reactions are common but usually mild and temporary.

Researchers are testing aluminum chloride hexahydrate (ACH) with 5-FU to see if it enhances the treatment's effectiveness. ACH, often used to stop bleeding from small cuts, is considered safe. However, its use with 5-FU for AK is still under study, and more information is needed to fully understand its safety.

Researchers are excited about the investigational treatment for actinic keratosis because it combines 5-fluorouracil (5-FU), a standard treatment, with 15% acetyl cysteine (ACH). This combination could enhance the effectiveness of 5-FU by improving its penetration and action on the lesions. Unlike the standard treatment that solely uses 5-FU, this new approach aims to target the lesions more effectively, potentially leading to better outcomes for patients with fewer applications. The addition of ACH is what makes this treatment stand out, offering a potentially more efficient solution for those dealing with actinic keratosis.

Research has shown that 5-fluorouracil (5-FU) effectively treats actinic keratoses (AKs), which are rough, scaly patches on the skin caused by sun damage. Studies have found that a 4% 5-FU cream can significantly reduce the number of these skin lesions, making it a good option for those with extensive skin damage. In this trial, participants will apply either a standard 5% 5-FU cream or an investigational cream combining 5% 5-FU with 15% aluminum chloride hexahydrate (ACH) to determine if ACH enhances the treatment's effectiveness. Early results suggest that aluminum may improve the cream's ability to reduce AKs. This combination is being tested to see if it provides better results than 5-FU alone.¹³⁶⁷⁸