Lateral Plantar Artery Embolization for Plantar Fasciitis

This trial explores a new procedure to determine if it can safely and effectively reduce chronic heel pain from plantar fasciitis. The treatment involves a doctor injecting a temporary blocking agent (Lipiodol) into specific blood vessels in the foot to relieve pain. The trial seeks individuals who have experienced persistent plantar fasciitis pain despite trying other treatments for at least three months and wish to avoid surgery. Participants will have follow-up calls and visits over a year to monitor their pain levels and any side effects. As a Phase 1 trial, this research aims to understand how the treatment works in people, offering participants the opportunity to be among the first to receive this innovative procedure.

The trial information does not specify if you need to stop taking your current medications. However, if you are on anticoagulation therapy, you may not be eligible to participate.

Research suggests that Lipiodol, used in a procedure for heel pain, is generally well-tolerated. Past studies on Lipiodol for similar treatments showed few serious side effects. Most patients experienced mild to moderate discomfort, which was temporary. Although research is still in the early stages, evidence so far indicates that Lipiodol is safe for treating heel pain from plantar fasciitis. However, as this is a Phase 1 trial, the main goal is to assess safety, with ongoing data collection to ensure no unexpected risks arise. Researchers closely monitor participants for any side effects, prioritizing safety.¹²³⁴⁵

Unlike the standard treatments for plantar fasciitis, which often involve physical therapy, anti-inflammatory medications, or steroid injections, Lipiodol in lateral plantar artery embolization targets the condition via a minimally invasive procedure. This treatment is unique because it works by reducing blood flow to the affected area, which may help decrease inflammation and pain more effectively than traditional methods. Researchers are excited about this approach because it offers a new mechanism of action that could provide relief for patients who haven't responded well to conventional therapies.

Research has shown that embolization therapy, which uses a substance called Lipiodol, might help reduce long-term heel pain from plantar fasciitis. In this trial, participants will undergo Lateral Plantar Artery Embolization using Lipiodol. One study found that 13 patients with this condition reported satisfaction after the procedure. Another study demonstrated that using Lipiodol to block certain blood vessels is both feasible and safe for treating pain. These early results suggest that targeting specific blood vessels in the foot could effectively manage heel pain. While more research is needed, the initial findings are promising.¹²³⁶⁷