Acupuncture for Breast Cancer Survivors

HL
HL
Overseen ByHongjin Li
Age: 18+
Sex: Female
Trial Phase: Phase 1
Sponsor: University of Illinois at Chicago
Must be taking: Endocrine therapy
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Approved in 4 JurisdictionsThis treatment is already approved in other countries

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores how acupuncture might assist women who have completed their main breast cancer treatments, such as surgery or chemotherapy, and are now experiencing issues like pain, fatigue, or sleep problems. Participants will receive acupuncture treatments twice a week for five weeks to determine if it can improve these symptoms. Women who have finished their primary treatment for stage 0 to III breast cancer in the past month and experience at least three of the following—pain, fatigue, sleep disturbance, depression, hot flashes, or anxiety—may be suitable for this study. As a Phase 1 trial, this research aims to understand how acupuncture works in people, offering participants the chance to be among the first to explore its potential benefits.

Do I have to stop taking my current medications for this trial?

The protocol does not specify if you need to stop taking your current medications. However, you must be currently taking endocrine therapy to participate.

What prior data suggests that acupuncture is safe for breast cancer survivors?

Research has shown that acupuncture is generally safe for cancer patients, including breast cancer survivors. Studies indicate it is as safe as sham acupuncture and other treatments. Some mild side effects, such as pain, bruising, swelling, or headache, might occur, but serious issues are very rare.

A review of several studies found that acupuncture can help with joint pain caused by cancer treatment. This suggests it can be a reliable and safe option for managing certain symptoms. Overall, acupuncture appears well-tolerated and offers a low-risk treatment choice for breast cancer survivors.12345

Why are researchers excited about this trial?

Unlike the standard treatments for breast cancer survivors, such as medication and physical therapy, acupuncture offers a non-invasive and holistic approach to managing symptoms. Researchers are excited about acupuncture because it aims to balance the body's energy, potentially reducing pain and fatigue without the side effects often associated with pharmaceuticals. This technique is distinct in its method of action: by stimulating specific points on the body, it may enhance overall well-being and provide relief more naturally.

What evidence suggests that acupuncture might be an effective treatment for breast cancer survivors?

Research has shown that acupuncture can benefit breast cancer survivors. A review of studies found that acupuncture might improve symptoms related to breast cancer treatment, such as pain, tiredness, and hot flashes. Many people report feeling better from acupuncture either immediately or after a few sessions. In this trial, participants in the acupuncture group will receive two acupuncture treatments each week for five weeks. Additionally, certain types of acupuncture, like electroacupuncture, have reduced long-term pain more effectively than standard care. These findings suggest that acupuncture may provide meaningful relief for symptoms experienced by breast cancer survivors.678910

Are You a Good Fit for This Trial?

This trial is for English-speaking women over 18 who've had stage 0-III breast cancer, finished primary treatment within the last month, and are on endocrine therapy. They must have moderate to severe pain, fatigue, sleep issues, depression, hot flashes or anxiety. Excluded are those with bleeding disorders, inability to attend weekly acupuncture sessions, certain psychiatric or medical conditions that affect assessments (like dementia), and those pregnant or planning pregnancy.

Inclusion Criteria

I have been diagnosed with early-stage breast cancer.
I've had significant pain, fatigue, sleep issues, depression, hot flashes, or anxiety recently.
I finished my main cancer treatment last month and am now on hormone therapy.

Exclusion Criteria

I cannot commit to weekly acupuncture clinic visits.
I do not have any mental health or neurological conditions that could affect study results.
I have a bleeding disorder like hemophilia.
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Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive 2 acupuncture treatments each week for 5 weeks, totaling 10 treatments

5 weeks
10 visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

6 weeks

Study Completion

Identify barriers and facilitators associated with implementing acupuncture

1 year

What Are the Treatments Tested in This Trial?

Interventions

  • Acupuncture
Trial Overview The study is examining how feasible it is to include acupuncture as a regular treatment in health centers for breast cancer survivors dealing with symptoms like pain and fatigue after their main cancer treatments have ended.
How Is the Trial Designed?
2Treatment groups
Experimental Treatment
Active Control
Group I: Acupuncture groupExperimental Treatment1 Intervention
Group II: Usual care groupActive Control1 Intervention

Acupuncture is already approved in United States, European Union, China for the following indications:

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Approved in United States as Acupuncture for:
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Approved in European Union as Acupuncture for:
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Approved in China as Acupuncture for:

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Illinois at Chicago

Lead Sponsor

Trials
653
Recruited
1,574,000+

Published Research Related to This Trial

In a study of 48 women recovering from breast cancer surgery, both acupuncture combined with kinesiotherapy and kinesiotherapy alone significantly improved pain, upper limb function, and range of motion after 10 treatment sessions.
While both treatment groups showed improvements, there were no significant differences in outcomes between the two groups, indicating that kinesiotherapy alone may be as effective as adding acupuncture for rehabilitation.
Effectiveness of acupuncture in rehabilitation of physical and functional disorders of women undergoing breast cancer surgery.Giron, PS., Haddad, CA., Lopes de Almeida Rizzi, SK., et al.[2018]
Acupuncture significantly reduces treatment-related symptoms such as pain intensity, fatigue, and hot flash severity in breast cancer survivors, based on a meta-analysis of 20 trials involving 1709 patients.
The treatment is generally safe, with only mild adverse events reported, but the studies had a high risk of bias, indicating a need for more rigorous trials to confirm these findings.
Acupuncture Improves Multiple Treatment-Related Symptoms in Breast Cancer Survivors: A Systematic Review and Meta-Analysis.Li, H., Schlaeger, JM., Jang, MK., et al.[2022]
Acupuncture may help reduce functional stiffness in breast cancer patients undergoing hormone therapy, based on a review of 17 randomized controlled trials involving 810 participants.
While acupuncture showed moderate effects on stiffness, it did not significantly alleviate other common side effects of hormone therapy, such as hot flashes and fatigue, indicating that its benefits may be limited to specific symptoms.
Clinical Benefits of Acupuncture for the Reduction of Hormone Therapy-Related Side Effects in Breast Cancer Patients: A Systematic Review.Pan, Y., Yang, K., Shi, X., et al.[2019]

Citations

Real-world experiences with acupuncture among breast ...Most participants reported time-to-benefit as immediate (34.4%) or after a few treatments (40.2%), few reported benefit after the final treatment (2.1%) or ...
Acupuncture for Breast Cancer: A Systematic Review and ...Conclusions: Current evidence suggests that acupuncture might improve BC treatment-related symptoms measured with PROs including QoL, pain, fatigue, hot flashes ...
Comparing the effects of different non-pharmacological ...Acupressure and Tai Chi/Qi Gong have significant efficacy in relieving cancer-related pain and improving quality of life. •. Acupressure is most effective ...
Real-world impact of acupuncture on analgesics and ...Breast cancer survivors who initiated acupuncture were found with an average decline in total healthcare cost by 26% (95% CI = 0.61 to 0.89, P < ...
Effectiveness of Electroacupuncture or Auricular ...Electroacupuncture and auricular acupuncture are more effective than usual care at reducing chronic musculoskeletal pain in cancer survivors.
Evidence, safety and recommendations for when to use ...Acupuncture is moderately or weakly effective for 19 symptoms in patients with cancer and cancer survivors. Acupuncture is a safe therapy in cancer care if ...
Safety of acupuncture in oncology: A systematic review and ...The current review indicates that acupuncture is as safe as sham acupuncture and active controls in oncological patients. The authors recommend ...
Acupuncture may ease breast cancer treatment side effectsAcupuncture is generally thought to be safe but it can cause mild reactions, including pain, bruising, swelling, skin infection, hematoma, headache or ...
Acupuncture: Effectiveness and Safety - nccIH.nih.govA 2017 review of 5 studies (181 participants) of acupuncture for aromatase inhibitor-induced joint pain in breast cancer patients concluded that 6 to 8 weeks ...
Efficacy and safety of acupuncture for the treatment ...Acupuncture can partially alleviate insomnia symptoms in breast cancer patients. Moreover, acupuncture is safe and may serve as a dependable alternative therapy ...
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