Botanical Therapy for Common Cold
(DPBT-AVRI Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This Phase 1 study will evaluate the feasibility and safety of implementing a host pathologic state-directed botanical therapeutic platform in adults with acute viral respiratory infections. The platform, called Dynamic Pathology-Based Therapy (DPBT), uses a predefined clinical algorithm to identify participants' pathological states and select the corresponding botanical formulation module or combination of modules.
Approximately 30 adults aged 18 to 80 will participate in this prospective, single-group, open-label study. All participants will receive the assigned DPBT intervention in addition to medically appropriate standard care. Treatment will generally continue for 7 days and may be extended through Day 10 if predefined pathological states persist. Study assessments will examine protocol implementation, recruitment and retention, adherence, treatment tolerability, adverse events, changes in symptoms and recovery, and exploratory changes in viral detection through Day 12.
Who Is on the Research Team?
Wanzhu Hou, L.Ac., CH., CMD, MD (CN)
Principal Investigator
All Natural Medicine Clinic, LLC
Are You a Good Fit for This Trial?
This trial is for adults aged 18 to 80 who currently have a viral respiratory infection like the common cold. Participants should be able to follow study instructions and will continue their usual medical care while trying the new botanical therapy.Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- PurClo Botanical Formulation
- PurCo Botanical Formulation
- PurInf I Botanical Formulation
- PurInf II Botanical Formulation
- PurInf III Botanical Formulation
- PurPhl Botanical Formulation
Trial Overview
The study tests several plant-based (botanical) treatments, chosen based on each person's symptoms using a special clinical approach called DPBT. All participants get these therapies along with standard care for up to 10 days in an open-label, single-group setting.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Participants in this single experimental arm will receive host pathologic state-directed botanical therapy using the predefined Dynamic Pathology-Based Therapy (DPBT) clinical algorithm, in addition to medically appropriate standard care. Based on the participant's presenting pathological state or combination of states, the algorithm will assign one or more of six botanical formulation modules: PurInf I for an upper-respiratory inflammatory state, PurInf II for a fever-predominant state, PurInf III for a lower-respiratory inflammatory state, PurCo for a cough-predominant state, PurPhl for a pathological-secretions state, and PurClo for a clot- and poor-circulation-related state. Assigned modules may be continued, added, removed, or discontinued according to protocol-defined reassessment. Treatment will generally continue for 7 days and may be extended through Day 10 if predefined pathological states persist.
Find a Clinic Near You
Who Is Running the Clinical Trial?
All Natural Medicine Clinic, LLC
Lead Sponsor
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