VIR-1388 Vaccine for HIV

Not yet recruiting at 1 trial location
Age: 18 - 65
Sex: Any
Trial Phase: Phase 1
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

What You Need to Know Before You Apply

What is the purpose of this trial?

This study is to test an experimental HIV Vaccine. About 12 participants, aged 18-55 years and who already have cytomegalovirus (CMV) will take part in this study. Participants will come to the clinic for scheduled visits about 21 times over 12 months.

Are You a Good Fit for This Trial?

This trial is for adults aged 18-55 who already have cytomegalovirus (CMV) and do not have HIV. Participants should be generally healthy and able to attend frequent clinic visits over a year.

Inclusion Criteria

Total measured serum calcium level >8.5 mg/dL
Aspartate aminotransferase (AST) <1.25 × upper limit of normal based on institutional normal range
Alkaline phosphatase (ALP) ≤1.1 × upper limit of normal based on institutional normal range
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Exclusion Criteria

History of generalized urticaria within past year
Childcare worker routinely caring for children under 2 years old
I have type 1 or 2 diabetes, but my blood sugar is well controlled.
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What Are the Treatments Tested in This Trial?

Interventions

  • VIR-1388

Trial Overview

The study is testing the safety and immune response of a higher dose of an experimental HIV vaccine called VIR-1388 compared to a placebo. About 12 participants will be randomly assigned to receive either the vaccine or placebo.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Placebo Group

Group I: VIR-1388Experimental Treatment1 Intervention
Group II: PlaceboPlacebo Group1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

National Institute of Allergy and Infectious Diseases (NIAID)

Lead Sponsor

Trials
3,361
Recruited
5,516,000+