Nerve Interface for Post-Mastectomy Pain

This trial tests a new approach to reduce nerve pain after breast cancer surgery. It uses a technique called Regenerative Peripheral Nerve Interface (RPNI), which protects nerves with a piece of muscle during surgery to prevent long-term pain, such as discomfort and tingling. The trial seeks women undergoing a mastectomy with immediate reconstruction who are willing to participate in follow-up surveys about their pain and quality of life. Participants will be randomly assigned to either receive the RPNI procedure or not, and researchers will track their progress for about a year. As an unphased trial, this study offers a unique opportunity to contribute to innovative research that could improve post-surgical outcomes for future patients.

The trial protocol does not specify whether you need to stop taking your current medications. It's best to discuss your specific situation with the study team.

Research has shown that the Regenerative Peripheral Nerve Interface (RPNI) is safe to use. In one study, patients who underwent RPNI for chronic pain after a mastectomy reported a significant reduction in pain levels post-surgery. Another study found that using RPNI during major limb amputation reduced pain and decreased the need for opioids, which are strong painkillers with potential side effects.

Researchers are excited about the Regenerative Peripheral Nerve Interface (RPNI) for post-mastectomy pain because it offers a new approach to managing nerve pain after breast cancer surgery. Unlike standard treatments like pain medications or nerve blocks, RPNI aims to directly interface with peripheral nerves to potentially reduce pain more effectively. This technique involves connecting a small piece of muscle to the severed nerve endings, which may help prevent painful neuroma formation and improve quality of life. By targeting the source of pain at the nerve level, it holds promise for providing longer-lasting relief than conventional methods.

Research has shown that the Regenerative Peripheral Nerve Interface (RPNI), which participants in this trial may receive, can greatly reduce pain for individuals experiencing post-mastectomy pain. In one study, patients reported their pain levels dropping from a 9 to a 1 after receiving RPNI treatment. Another study found that those treated with RPNI experienced fewer nerve pain symptoms. These findings suggest that RPNI may help prevent and reduce long-term nerve pain after breast cancer surgery.¹⁶⁷⁸⁹