80 Participants Needed

Motivation Skills Training for Serious Mental Illness

(MST Trial)

Recruiting at 1 trial location
AS
AM
Overseen ByAlice Medalia, PhD
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests a new therapy called Motivation Skills Training (MST) for individuals with schizophrenia or schizoaffective disorder. The researchers aim to determine if MST improves motivation and the ability to set and achieve personal goals. Participants will attend weekly group sessions focusing on either motivation skills (MST) or healthy behaviors (HBC) over 12-14 weeks. Suitable candidates have been diagnosed with schizophrenia or schizoaffective disorder, are stable outpatients, and can speak English. As an unphased trial, this study provides a unique opportunity to contribute to innovative research that could enhance personal goal-setting and motivation strategies.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It seems likely that you can continue your medications since the trial focuses on motivation skills training and not on medication changes.

What prior data suggests that Motivation Skills Training is safe for individuals with serious mental illness?

Research has shown that Motivation Skills Training (MST) is under study to determine its safety and effectiveness for individuals with serious mental illnesses like schizophrenia. Some studies have examined participants' responses to this training and suggest that MST is generally well-tolerated, with few problems or side effects reported.

The study is labeled as "Not Applicable" in terms of phase, indicating that MST focuses more on therapy than on introducing new drugs. This approach typically involves lower risks, as it emphasizes skill development in a group setting. So far, no major issues or safety concerns have been reported.

Participants in the trial will likely attend weekly group sessions that concentrate on motivation and self-regulation, helping them better manage and understand their own motivation. Overall, MST aims to support improved motivation and goal-setting without significant safety concerns.12345

Why are researchers excited about this trial?

Researchers are excited about Motivation Skills Training (MST) because it offers a unique approach to managing serious mental illness. Unlike standard treatments that often focus on medication or traditional therapy, MST is a group-based skills training intervention designed to help individuals understand and manage their motivation. By improving self-awareness and the ability to regulate motivation, MST aims to enhance a person's ability to initiate and sustain goal-directed behavior, potentially leading to better long-term outcomes. This focus on motivation as a key driver of behavior is what sets MST apart from existing options.

What evidence suggests that this trial's treatments could be effective for serious mental illness?

This trial will compare Motivation Skills Training (MST) with a Healthy Behaviors Control Group. Research shows that MST helps people with serious mental illnesses, like schizophrenia, improve their motivation. MST focuses on helping individuals understand their drives and teaches skills to stay focused on their goals. Although specific data on MST's effectiveness for schizophrenia is limited, similar community programs have positively affected social interactions and quality of life. These programs often help people develop better coping strategies and improve daily living skills. MST aims to increase motivation, which is often challenging for those with serious mental illnesses, potentially leading to better condition management.12678

Who Is on the Research Team?

AS

Alice Saperstein, PhD

Principal Investigator

Columbia University

Are You a Good Fit for This Trial?

Adults aged 18-65 with schizophrenia or schizoaffective disorder, who speak English and are stable enough to attend outpatient therapy. They shouldn't have intellectual disabilities (IQ <70), severe recent substance use, or brain diseases due to neurological conditions.

Inclusion Criteria

English Fluency
I am stable both physically and mentally.
I have been diagnosed with Schizophrenia or Schizoaffective Disorder.

Exclusion Criteria

Indications of Intellectual Disability as documented in medical history or measured by < 70 premorbid full scale Intelligence Quotient (IQ) estimate
Severe substance use within the past three months determined by DSM-5 criteria
I have a brain condition due to a neurological issue.
See 1 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Baseline Assessment

Participants undergo baseline assessments including sociodemographic and psychosocial assessments, measures of motivation, goal attainment, and quality of life, as well as measures of executive skills, community functioning, and psychiatric symptoms severity

1 week

Treatment

Participants receive weekly group-based interventions, either Motivation Skills Training (MST) or Healthy Behaviors Control (HBC), focusing on motivation and self-regulation skills or physical health and health-related skills, respectively

12-14 weeks
12-14 visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment, with assessments of functional outcomes, motivation, and quality of life

5 months

What Are the Treatments Tested in This Trial?

Interventions

  • Healthy Behaviors Control Group
  • Motivation Skills Training
Trial Overview The trial is testing Motivation Skills Training (MST) against a Healthy Behaviors Control group in people with serious mental illness. Participants will attend weekly group sessions for about 12-14 weeks focusing on either motivation and self-regulation skills (MST) or physical health (HBC).
How Is the Trial Designed?
2Treatment groups
Experimental Treatment
Active Control
Group I: Motivation Skills Training (MST)Experimental Treatment1 Intervention
Group II: Healthy Behaviors Control GroupActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Columbia University

Lead Sponsor

Trials
1,529
Recruited
2,832,000+

National Institute of Mental Health (NIMH)

Collaborator

Trials
3,007
Recruited
2,852,000+

Published Research Related to This Trial

In a study of 404 individuals aged 15-40 who experienced their first episode of schizophrenia spectrum disorder, motivation was found to significantly influence later work and school participation, but not vice versa.
Social functioning at 6 months was linked to increased motivation at 12 months, suggesting that enhancing social interactions may help improve motivation in patients following their first psychotic episode.
Prospective Relationships Between Motivation and Functioning in Recovery After a First Episode of Schizophrenia.Fulford, D., Piskulic, D., Addington, J., et al.[2019]
Motivation plays a crucial role in the success of skills-based psychosocial treatments for schizophrenia, particularly in cognitive remediation, where intrinsic motivation (IM) is linked to better learning outcomes.
The article explores whether IM in individuals with schizophrenia is changeable and how manipulating motivation can enhance learning, suggesting that tailored motivational strategies could improve treatment effectiveness.
The role of motivation for treatment success.Medalia, A., Saperstein, A.[2021]
Social skills training is effective for individuals with schizophrenia, helping them acquire essential interpersonal and independent living skills, which can improve their functioning in the community.
Recent advancements in social skills training have tailored approaches for various groups, including those with dual diagnoses and older adults, enhancing the generalization of skills to real-life situations.
Recent advances in social skills training for schizophrenia.Kopelowicz, A., Liberman, RP., Zarate, R.[2022]

Citations

Effectiveness of Motivation Skills Training (MST)This study will take place at four outpatient clinics serving adults with serious mental illness. Informed consent will be obtained from N=80 individuals ...
Work Motivation and Employment Outcomes in People with ...The results of this study show no statistically significant associations between the level of work motivation and employment outcomes in people ...
Motivation Skills Training for Serious Mental IllnessThe MST medical study, being run by Columbia University, is evaluating whether Motivation Skills Training will have tolerable side effects & efficacy for ...
Effectiveness of Motivation Skills Training (MST)This study will take place at four outpatient clinics serving adults with serious mental illness. Informed consent will be obtained from ...
Community‐based social interventions for people with severe ...Over half reported on the effectiveness of interventions delivered at the service level (supported accommodation, education or employment), ...
Motivating factors and barriers towards exercise in severe ...Many of the desirable outcomes of exercise for people with SMI, such as mood improvement, stress reduction and increased energy, are inversely related to the ...
Effectiveness of Motivation Skills Training (MST)This study will take place at four outpatient clinics serving adults with serious mental illness. Informed consent will be obtained from ...
Experiences of exercise services for individuals with ...Exercise helps manage severe mental illness symptoms, providing clarity and stress reduction. Exercise enhances emotional outcomes, confidence, and motivation.
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