Magnesium Therapy for Postoperative Pain

This trial explores whether IV magnesium (magnesium therapy) during surgery can reduce pain for individuals undergoing periacetabular osteotomy (PAO). Participants will be divided into two groups: one will receive IV magnesium with standard pain management, while the other will receive only standard care. The study seeks participants planning to undergo PAO, with or without an additional hip procedure. It is not suitable for those with certain heart issues, such as AV block, severe kidney problems, or heart failure. As a Phase 4 trial, this research aims to understand how the already FDA-approved and effective treatment benefits more patients.

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

Research shows that IV magnesium sulfate is usually well-tolerated for managing post-surgical pain. Studies have found it can reduce pain and decrease the need for opioids, which are strong painkillers. As a result, patients often feel better and require less medication to manage their pain.

Regarding safety, previous research has not identified significant adverse side effects when using it for pain control. Patients who received magnesium sulfate reported less severe pain both immediately after surgery and the following day.

Researchers are excited about using IV magnesium sulfate for postoperative pain because it offers a unique approach compared to standard pain management options like opioids and NSAIDs. Unlike these typical treatments, magnesium sulfate works by blocking specific receptors in the nervous system that are involved in pain transmission, potentially leading to effective pain relief with fewer side effects. Additionally, magnesium sulfate is administered intravenously, allowing for precise control over dosage and rapid action, which can be particularly beneficial in a surgical setting. This method has the potential to reduce reliance on opioids, addressing concerns about addiction and side effects associated with traditional pain medications.

Research shows that IV magnesium sulfate, which participants in this trial may receive, can help reduce post-surgical pain. Studies have found that it lowers pain levels and reduces the need for strong painkillers like opioids after surgeries, including abdominal and spine operations. One study found that magnesium sulfate reduced pain six hours after surgery and decreased morphine use. Another study noted that patients required fewer pain medications during and after their surgeries when they received magnesium sulfate. Overall, magnesium sulfate has shown promise in easing post-surgical pain and reducing the need for painkillers.¹²⁶⁷⁸