Insulin for Obesity
What You Need to Know Before You Apply
What is the purpose of this trial?
Determine the impact of obesity with insulin resistance on the neurovascular response to brain insulin stimulation.
Are You a Good Fit for This Trial?
This trial is for adults aged 18-65 who are either healthy and normal weight (BMI 18-25) or have obesity with insulin resistance (BMI 30-45). Participants must not smoke, be pregnant, have major health issues like heart disease or diabetes, or recent large weight changes.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive human insulin (160 IU) administered using an intra-nasal device
Follow-up
Participants are monitored for changes in muscle sympathetic nerve activity, cerebral blood flow, and leg blood flow
What Are the Treatments Tested in This Trial?
Interventions
- human insulin
Trial Overview
The study tests how the body’s blood vessels respond to insulin in people with and without obesity-related insulin resistance. Human insulin is given to see its effects on brain and body blood flow.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Human insulin (160 IU) will be administered using an intra-nasal device.
Human insulin (160 IU) will be administered using an intra-nasal device
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Missouri-Columbia
Lead Sponsor
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