Collagenase Injection for Muscle Spasticity

SL
SL
Overseen ByShengai Li, MS
Age: 18+
Sex: Any
Trial Phase: Phase < 1
Sponsor: The University of Texas Health Science Center, Houston
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

The overall goal is to investigate the effectiveness of a novel intervention - Collagenase injection, for spasticity management in patients with neurological impairments, such as stroke, brain injury, and spinal cord injury.

Who Is on the Research Team?

SL

Sheng Li, MD, PhD

Principal Investigator

The University of Texas Health Science Center, Houston

Are You a Good Fit for This Trial?

This trial is for people with muscle spasticity or stiffness due to neurological conditions like stroke, brain injury, or spinal cord injury. Participants should not have other major health issues that would make the treatment unsafe.

Inclusion Criteria

MAS ≥ 1
I had a stroke or injury over 6 months ago and my condition is stable.

Exclusion Criteria

Is hypersensitive to XIAFLEX or collagenase
Has heritable connective tissue disorders, including those within the Ehlers-Danlos syndrome (EDS) spectrum
I have had a botulinum toxin injection in the target area within the last 4 months.
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What Are the Treatments Tested in This Trial?

Interventions

  • XIAFLEX Collagenase injection

Trial Overview

The study is testing XIAFLEX Collagenase injections to see if they help reduce muscle tightness and improve movement in people with spasticity from nerve injuries.

How Is the Trial Designed?

1

Treatment groups

Experimental Treatment

Group I: Active XIAFLEX Collagenase injectionExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

The University of Texas Health Science Center, Houston

Lead Sponsor

Trials
974
Recruited
361,000+