LpD3.5 for Mild Cognitive Impairment
(Postbiotics Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This randomized placebo-controlled clinical study, called the LpD3.5 Intervention Study in Older Adults (LISA), aims to evaluate whether a heat-inactivated postbiotic of human origin (LpD3.5) can serve as a non-pharmacological intervention to reduce gut permeability and inflammation in older adults with mild cognitive impairment (MCI). The study will assess the effects of LpD3.5 supplementation on markers associated with gut health, inflammation, microbiome composition, and cognitive function.
Participants aged 60 years or older with clinically diagnosed MCI will receive either LpD3.5 capsules or placebo capsules for 60 days, followed by a 30-day follow-up period. Biological samples and clinical assessments will be collected to evaluate changes in gut permeability, inflammatory markers, microbiome characteristics, and cognitive outcomes. The findings from this study may provide insight into the potential role of postbiotics as a dietary intervention to improve gut health and related outcomes in older adults with MCI.
Are You a Good Fit for This Trial?
This trial is for adults aged 60 or older who have been clinically diagnosed with mild cognitive impairment (MCI).What Are the Treatments Tested in This Trial?
Interventions
- LpD3.5
Trial Overview
The study tests whether a heat-inactivated postbiotic supplement called LpD3.5 can improve gut health and reduce inflammation in older adults with MCI, compared to a placebo. Participants are randomly assigned to receive either LpD3.5 or placebo capsules daily for 60 days.
How Is the Trial Designed?
2
Treatment groups
Active Control
Placebo Group
This group will receive LpD3.5 (2 capsules per day) for a duration of 60 days with follow-up at 90-day.
They will receive a bottle of placebo capsules (2 capsules per day) for a duration of 60 days with follow-up at 90 days
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of South Florida
Lead Sponsor
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