Lysine Chloride for Heart Failure

This trial explores the effects of lysine chloride, a sodium-free chloride supplement, on patients with stable heart failure. Researchers aim to understand its impact on electrolyte balance and overall fluid levels in the body. Participants will receive either lysine chloride or a placebo three times a day for five days. The trial seeks individuals with heart failure who have not been hospitalized in the past 90 days, are on stable medication, and have a low serum chloride level. As an Early Phase 1 trial, this research focuses on understanding how the treatment works in people, offering participants a chance to be among the first to receive this new treatment.

The trial requires that you stay on your current heart failure medications, but you may need to stop taking metformin during certain parts of the study. If you are using a thiazide diuretic or certain chloride-containing medications, you may need to stop those as well.

Research has shown that lysine chloride is generally safe for humans. Studies have found that ʟ-lysine hydrochloride, similar to lysine chloride, is well-tolerated by people. It has been used in dietary supplements at doses up to 3.75 grams per day without causing major side effects. Additionally, taking lysine supplements usually does not lead to many negative effects. This suggests that lysine chloride might be safe to use. However, since this trial is in an early stage, researchers are closely monitoring it to ensure safety.¹²³⁴⁵

Lysine chloride is unique because it offers a new approach to treating heart failure by potentially impacting blood volume management. Unlike the standard treatments, which often focus on improving heart function or reducing symptoms through medications like beta-blockers and ACE inhibitors, lysine chloride might work by directly influencing the body's fluid balance. Researchers are excited about this treatment because it could provide a quicker, more effective way to relieve symptoms of heart failure, with patients possibly seeing benefits within just days of starting therapy. If successful, this could represent a significant advancement in managing heart failure, offering hope to patients who need faster relief.

This trial will compare Lysine Chloride with a placebo to evaluate its effects on heart failure. Research has shown that lysine supplements may benefit heart health. One study found that lysine improved the heart and blood vessels' ability to handle stress, suggesting it could support heart health by managing stress. Lysine is also safe for consumption, even in larger amounts. While this trial continues to investigate Lysine Chloride for heart failure, these early findings are promising and suggest it might help improve heart function.¹²⁶⁷⁸