Metformin for Muscle Weakness
What You Need to Know Before You Apply
What is the purpose of this trial?
The purpose of this research study is to determine if Metformin taken after anterior cruciate ligament reconstruction (ACLR) surgery can decrease muscle fibrosis, cellular senescence and improve leg strength. ACL injury and surgery increase muscle collagen content and inflammation which slows the recovery of muscle and function and ultimately impacts the quality of life. Individuals enrolled in the study will be randomized to receive metformin (or placebo) for 4 months after surgery. The investigators will measure muscle strength and inflammatory markers in muscle biopsy samples after the intervention period. Investigators will also follow up with participants 8 months later to determine the lasting effects of the intervention.
Who Is on the Research Team?
Micah Drummond
Principal Investigator
University of Utah
Are You a Good Fit for This Trial?
This trial is for people who have had ACL reconstruction surgery and are recovering from it. Participants should be experiencing muscle weakness or inflammation after their surgery. Specific inclusion and exclusion criteria were not listed.Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- Metformin
Trial Overview
The study tests whether taking metformin for 4 months after ACL surgery helps reduce muscle scarring, aging of cells, and improves leg strength compared to a placebo. Participants are randomly assigned to either the metformin or placebo group.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Placebo Group
Individuals randomized to metformin group will take the intervention daily for 4 months after ACLR surgery
Individuals randomized to placebo group will take the treatment daily for 4 months after ACLR surgery
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Utah
Lead Sponsor
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