Steven Polyak | University of Iowa ...

Dr. Steven Polyak, MD

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Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics

Studies Crohn's Disease
Studies Ulcerative Colitis
7 reported clinical trials
6 drugs studied

Affiliated Hospitals

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Holden Comprehensive Cancer Center, University Of Iowa Hospitals And Clinics

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University Of Iowa Hospitals And Clinics

Clinical Trials Steven Polyak, MD is currently running

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Obefazimod

for Crohn's Disease

This study has 3 treatment phases, a 12-Week Induction Phase, a 40-Week Maintenance Phase, and a 48-Week Extension Phase. The objective is to evaluate the efficacy and safety of obefazimod compared to placebo as induction and maintenance therapy in subjects with moderately to severely active CD after inadequate response (no response, loss of response, or intolerance) to conventional therapies and/or advanced therapies. The primary objective for the 48-Week Extension Phase is to evaluate the safety and tolerability of obefazimod compared with placebo in subjects who are enrolled in the Extension Phase.

Recruiting

0 awards

Phase 2

4 criteria

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TAK-279

for Crohn's Disease

Crohn's disease (CD) is a long-lasting condition causing inflammation that can affect any part of the gut. The purpose of this study is to evaluate the efficacy and safety of TAK-279 versus placebo in participants with moderately to severely active Crohn's disease (CD). The main aim of this study is to learn if the 3 different doses of TAK-279 reduce bowel inflammation and ulcers in the bowel compared to the placebo after 12 weeks of treatment. Another aim is to compare any medical problems that participants have when they take TAK-279 or placebo and how well the participants tolerate medical problems. An endoscopy will be used to check the bowel for inflammation. The participants will be treated with TAK-279 for 52 weeks (1 year). During the study, participants will visit their study clinic 15 times.

Recruiting

0 awards

Phase 2

4 criteria

More about Steven Polyak, MD

Clinical Trial Related

1 year of experience running clinical trials · Led 7 trials as a Principal Investigator · 2 Active Clinical Trials

Treatments Steven Polyak, MD has experience with

  • TAK-279
  • ABX464
  • CDPATH™
  • Placebo
  • BMS-986165
  • Obefazimod

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