Selina Laqui | UC Davis Graduate School ...

Dr. Selina Laqui, MD, PhD

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University of California Davis Comprehensive Cancer Center

Studies Oligoprogressive
Studies Prostate Cancer
10 reported clinical trials
20 drugs studied

Area of expertise

1

Oligoprogressive

Selina Laqui, MD, PhD has run 4 trials for Oligoprogressive. Some of their research focus areas include:

Stage IV
2

Prostate Cancer

Selina Laqui, MD, PhD has run 3 trials for Prostate Cancer. Some of their research focus areas include:

Stage IV
BRCA2 positive
MSI positive

Affiliated Hospitals

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University Of California Davis Comprehensive Cancer Center

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University Of California, Davis

Clinical Trials Selina Laqui, MD, PhD is currently running

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Loncastuximab Tesirine + Rituximab

for Diffuse Large B-Cell Lymphoma

This phase II trial evaluates whether loncastuximab tesirine and rituximab followed by dose-adjusted doxorubicin, etoposide, vincristine, cyclophosphamide, and prednisone works to treat patients with high risk diffuse large B-cell lymphoma. Loncastuximab tesirine is a monoclonal antibody called loncastuximab, linked to a drug called tesirine. It is a form of targeted therapy because it attaches to specific molecules (receptors) on the surface of cancer cells, known as CD19 receptors, and delivers tesirine to kill them. Rituximab is a monoclonal antibody. It binds to a protein called CD20, which is found on B cells (a type of white blood cell) and some types of cancer cells. This may help the immune system kill cancer cells. Chemotherapy drugs such as doxorubicin, vincristine, and cyclophosphamide work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Etoposide is in a class of medications known as podophyllotoxin derivatives. It blocks a certain enzyme needed for cell division and DNA repair and may kill cancer cells. Prednisone is in a class of medications called corticosteroids. It is used to reduce inflammation and lower the body's immune response to help lessen the side effects of chemotherapy drugs. Giving loncastuximab tesirine and rituximab in combination with dose-adjusted doxorubicin, etoposide, vincristine, cyclophosphamide, and prednisone may be more effective at treating high risk diffuse large B-cell lymphoma patients than standard treatments.

Recruiting

1 award

Phase 2

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Ablative Therapy

for Gastrointestinal Cancer

This is a phase 2 pragmatic study that evaluates the clinical benefit of continuing systemic therapy with the addition of locally ablative therapies for oligo-progressive solid tumors as the primary objective. The primary outcome measure is the time to treatment failure (defined as time to change in systemic failure or permanent discontinuation of therapy) following locally ablative therapy.

Recruiting

1 award

N/A

14 criteria

More about Selina Laqui, MD, PhD

Clinical Trial Related

4 years of experience running clinical trials · Led 10 trials as a Principal Investigator · 5 Active Clinical Trials

Treatments Selina Laqui, MD, PhD has experience with

  • Cyclophosphamide
  • Locally Ablative Therapy
  • Venetoclax
  • Locally Ablative Therapy
  • Etoposide
  • Rituximab

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