Richard G. Moore, M.D. | UR Medicine

Dr. Richard G. Moore

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University of Rochester

Studies Endometrial Adenocarcinoma
Studies Uterine Cancer
13 reported clinical trials
28 drugs studied

Area of expertise

1

Endometrial Adenocarcinoma

Richard G. Moore has run 6 trials for Endometrial Adenocarcinoma. Some of their research focus areas include:

Stage IV
Stage I
Stage III
2

Uterine Cancer

Richard G. Moore has run 5 trials for Uterine Cancer. Some of their research focus areas include:

Stage I
Stage III
Stage IV

Affiliated Hospitals

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University Of Rochester

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Highland Hospital

Clinical Trials Richard G. Moore is currently running

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Herceptin Hylecta or Phesgo + Chemotherapy

for Uterine Cancer

This phase III trial tests whether adding trastuzumab and hyaluronidase-oysk (Herceptin Hylecta \[TM\]) or pertuzumab, trastuzumab and hyaluronidase-zzxf (Phesgo \[TM\]) to the usual chemotherapy (paclitaxel and carboplatin) works to shrink tumors in patients with HER2 positive endometrial cancer. Trastuzumab and pertuzumab are monoclonal antibodies and forms of targeted therapy that attach to specific molecules (receptors) on the surface of tumor cells, known as HER2 receptors. When trastuzumab or pertuzumab attach to HER2 receptors, the signals that tell the cells to grow are blocked and the tumor cell may be marked for destruction by the body's immune system. Hyaluronidase is an endoglycosidase. It helps to keep pertuzumab and trastuzumab in the body longer, so that these medications will have a greater effect. Hyaluronidase also allows trastuzumab and trastuzumab/pertuzumab to be given by injection under the skin and shortens their administration time compared to trastuzumab or pertuzumab alone. Paclitaxel is a taxane and in a class of medications called antimicrotubule agents. It stops tumor cells from growing and dividing and may kill them. Carboplatin is in a class of medications known as platinum-containing compounds. It works in a way similar to the anticancer drug cisplatin, but may be better tolerated than cisplatin. Carboplatin works by killing, stopping or slowing the growth of tumor cells. Giving Herceptin Hylecta or Phesgo in combination with paclitaxel and carboplatin may shrink the tumor and prevent the cancer from coming back in patients with HER2 positive endometrial cancer.

Recruiting

2 awards

Phase 3

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CA 125 Blood Test

for Early Detection of Ovarian Cancer

The goal of this clinical research study is to find out if combining a standard blood test (CA-125) that checks for ovarian cancer with other blood tests that check for related tumor markers may be helpful in the early detection of ovarian cancer in women who are at low risk. Tumor markers are substances in the blood that may be related to ovarian cancer.

Recruiting

1 award

N/A

7 criteria

More about Richard G. Moore

Clinical Trial Related

3 years of experience running clinical trials · Led 13 trials as a Principal Investigator · 4 Active Clinical Trials

Treatments Richard G. Moore has experience with

  • Carboplatin
  • External Beam Radiation Therapy
  • Pembrolizumab
  • Cisplatin
  • Laboratory Biomarker Analysis
  • Paclitaxel

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