Dr. Randa Tao

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Huntsman Cancer Institute/University of Utah

Studies Esophageal Cancer
Studies Esophageal Adenocarcinoma
4 reported clinical trials
11 drugs studied

Area of expertise

1

Esophageal Cancer

Randa Tao has run 3 trials for Esophageal Cancer. Some of their research focus areas include:

Stage IV
HER2 negative
Stage I
2

Esophageal Adenocarcinoma

Randa Tao has run 2 trials for Esophageal Adenocarcinoma. Some of their research focus areas include:

Stage IV
HER2 negative
Stage I

Affiliated Hospitals

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Huntsman Cancer Institute/University Of Utah

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University Of Utah Sugarhouse Health Center

Clinical Trials Randa Tao is currently running

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Hypoxia-Guided Radiation

for Esophageal Cancer

This is a Phase I trial evaluating the safety of personalized radiation therapy based on levels of hypoxia identified on FMISO-PET and MRI. All patients will receive a baseline FMISO positron emission tomography (PET) and MRI to identify levels of hypoxia. Patients with tumor hypoxia will receive a higher dose of radiation therapy. Subjects who do not have hypoxic tumors will be treated with the standard-of-care radiation regimen. After fraction 10 of radiation therapy, an additional MRI will be performed. If this interim MRI demonstrates little or no response (as defined in Section 6), an optional boost radiation dose can be administered. Trial enrollment will be conducted in two parts. In Part 1, eight patients will be enrolled. After all eight patients have completed the 30 day dose-limiting toxicity (DLT) period, enrollment will be placed on hold and safety will be evaluated. During the interim analysis, one additional patient will be allowed to be enrolled in the trial. If the trial meets stopping rules as described in Section 11.3, the trial will be re-evaluated by the Data and Safety Monitoring Committee (DSMC) and the Principal Investigator. However, if the rate of DLTs remains below the unacceptable toxicity rate, enrollment will open to the enrollment of eight more patients.

Recruiting

1 award

Phase 1

7 criteria

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Ablative Therapy + Systemic Therapy

for Colorectal Cancer

This phase III trial compares total ablative therapy and usual systemic therapy to usual systemic therapy alone in treating patients with colorectal cancer that has spread to up to 4 body sites (limited metastatic). The usual approach for patients who are not participating in a study is treatment with intravenous (IV) (through a vein) and/or oral medications (systemic therapy) to help stop the cancer sites from getting larger and the spread of the cancer to additional body sites. Ablative means that the intention of the local treatment is to eliminate the cancer at that metastatic site. The ablative local therapy will consist of very focused, intensive radiotherapy called stereotactic ablative radiotherapy (SABR) with or without surgical resection and/or microwave ablation, which is a procedure where a needle is temporarily inserted in the tumor and heat is used to destroy the cancer cells. SABR, surgical resection, and microwave ablation have been tested for safety, but it is not scientifically proven that the addition of these treatments are beneficial for your stage of cancer. The addition of ablative local therapy to all known metastatic sites to the usual approach of systemic therapy could shrink or remove the tumor(s) or prevent the tumor(s) from returning.

Recruiting

2 awards

Phase 3

More about Randa Tao

Clinical Trial Related

5 years of experience running clinical trials · Led 4 trials as a Principal Investigator · 2 Active Clinical Trials

Treatments Randa Tao has experience with

  • Radiation Therapy
  • FMISO PET CT
  • Capecitabine
  • Fluorouracil
  • Leucovorin
  • Oxaliplatin

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