Patrick W. Cobb, MD - Billings, MT ...

Dr. Patrick Cobb, MD

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St. Vincent Frontier Cancer Center

Studies Breast Cancer
Studies Non-Small Cell Lung Cancer
24 reported clinical trials
48 drugs studied

Area of expertise

1

Breast Cancer

Patrick Cobb, MD has run 4 trials for Breast Cancer. Some of their research focus areas include:

Stage IV
HER2 negative
BRCA positive
2

Non-Small Cell Lung Cancer

Patrick Cobb, MD has run 3 trials for Non-Small Cell Lung Cancer. Some of their research focus areas include:

Stage IV
Stage III
BRAF negative

Affiliated Hospitals

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St Vincent Frontier Cancer Center

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Saint Vincent Frontier Cancer Center

Clinical Trials Patrick Cobb, MD is currently running

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Nivolumab + Standard Treatment

for Stomach and Esophageal Cancer

This phase II/III trial compares the addition of nivolumab to the usual treatment of paclitaxel and ramucirumab to paclitaxel and ramucirumab alone in treating patients with gastric or esophageal adenocarcinoma that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced). A monoclonal antibody is a type of protein that can bind to certain targets in the body, such as molecules that cause the body to make an immune response (antigens). Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Ramucirumab is a monoclonal antibody that may prevent the growth of new blood vessels that tumors need to grow. Paclitaxel is in a class of medications called antimicrotubule agents. It stops cancer cells from growing and dividing and may kill them. Adding nivolumab to ramucirumab and paclitaxel may work better to treat patients with advanced stomach or esophageal cancer.

Recruiting

1 award

Phase 2 & 3

20 criteria

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Herceptin Hylecta or Phesgo + Chemotherapy

for Uterine Cancer

This phase III trial tests whether adding trastuzumab and hyaluronidase-oysk (Herceptin Hylecta \[TM\]) or pertuzumab, trastuzumab and hyaluronidase-zzxf (Phesgo \[TM\]) to the usual chemotherapy (paclitaxel and carboplatin) works to shrink tumors in patients with HER2 positive endometrial cancer. Trastuzumab and pertuzumab are monoclonal antibodies and forms of targeted therapy that attach to specific molecules (receptors) on the surface of tumor cells, known as HER2 receptors. When trastuzumab or pertuzumab attach to HER2 receptors, the signals that tell the cells to grow are blocked and the tumor cell may be marked for destruction by the body's immune system. Hyaluronidase is an endoglycosidase. It helps to keep pertuzumab and trastuzumab in the body longer, so that these medications will have a greater effect. Hyaluronidase also allows trastuzumab and trastuzumab/pertuzumab to be given by injection under the skin and shortens their administration time compared to trastuzumab or pertuzumab alone. Paclitaxel is a taxane and in a class of medications called antimicrotubule agents. It stops tumor cells from growing and dividing and may kill them. Carboplatin is in a class of medications known as platinum-containing compounds. It works in a way similar to the anticancer drug cisplatin, but may be better tolerated than cisplatin. Carboplatin works by killing, stopping or slowing the growth of tumor cells. Giving Herceptin Hylecta or Phesgo in combination with paclitaxel and carboplatin may shrink the tumor and prevent the cancer from coming back in patients with HER2 positive endometrial cancer.

Recruiting

2 awards

Phase 3

More about Patrick Cobb, MD

Clinical Trial Related

7 years of experience running clinical trials · Led 24 trials as a Principal Investigator · 4 Active Clinical Trials

Treatments Patrick Cobb, MD has experience with

  • Carboplatin
  • Pembrolizumab
  • Placebo
  • Pemetrexed
  • Rituximab
  • Atezolizumab

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