Mary Tilley Jenkins Vogel, M.D. ...

Dr. Mary T Jenkins Vogel, MD

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NorthShore University HealthSystem-Evanston Hospital

Studies Ovarian Cancer
Studies Ovarian Carcinoma
13 reported clinical trials
42 drugs studied

Area of expertise

1

Ovarian Cancer

Mary T Jenkins Vogel, MD has run 7 trials for Ovarian Cancer. Some of their research focus areas include:

Stage IV
Stage III
Stage II
2

Ovarian Carcinoma

Mary T Jenkins Vogel, MD has run 5 trials for Ovarian Carcinoma. Some of their research focus areas include:

Stage I
Stage IV
Stage II

Affiliated Hospitals

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NorthShore University HealthSystem-Evanston Hospital

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NorthShore University HealthSystem-Highland Park Hospital

Clinical Trials Mary T Jenkins Vogel, MD is currently running

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Chemotherapy

for Cancer

This phase III trial studies how well active surveillance help doctors to monitor subjects with low risk germ cell tumors for recurrence after their tumor is removed. When the germ cell tumor has spread outside of the organ in which it developed, it is considered metastatic. Chemotherapy drugs, such as bleomycin, carboplatin, etoposide, and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. The trial studies whether carboplatin or cisplatin is the preferred chemotherapy to use in treating metastatic standard risk germ cell tumors.

Recruiting

2 awards

Phase 3

26 criteria

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Herceptin Hylecta or Phesgo + Chemotherapy

for Uterine Cancer

This phase III trial tests whether adding trastuzumab and hyaluronidase-oysk (Herceptin Hylecta \[TM\]) or pertuzumab, trastuzumab and hyaluronidase-zzxf (Phesgo \[TM\]) to the usual chemotherapy (paclitaxel and carboplatin) works to shrink tumors in patients with HER2 positive endometrial cancer. Trastuzumab and pertuzumab are monoclonal antibodies and forms of targeted therapy that attach to specific molecules (receptors) on the surface of tumor cells, known as HER2 receptors. When trastuzumab or pertuzumab attach to HER2 receptors, the signals that tell the cells to grow are blocked and the tumor cell may be marked for destruction by the body's immune system. Hyaluronidase is an endoglycosidase. It helps to keep pertuzumab and trastuzumab in the body longer, so that these medications will have a greater effect. Hyaluronidase also allows trastuzumab and trastuzumab/pertuzumab to be given by injection under the skin and shortens their administration time compared to trastuzumab or pertuzumab alone. Paclitaxel is a taxane and in a class of medications called antimicrotubule agents. It stops tumor cells from growing and dividing and may kill them. Carboplatin is in a class of medications known as platinum-containing compounds. It works in a way similar to the anticancer drug cisplatin, but may be better tolerated than cisplatin. Carboplatin works by killing, stopping or slowing the growth of tumor cells. Giving Herceptin Hylecta or Phesgo in combination with paclitaxel and carboplatin may shrink the tumor and prevent the cancer from coming back in patients with HER2 positive endometrial cancer.

Recruiting

2 awards

Phase 3

More about Mary T Jenkins Vogel, MD

Clinical Trial Related

7 years of experience running clinical trials · Led 13 trials as a Principal Investigator · 3 Active Clinical Trials

Treatments Mary T Jenkins Vogel, MD has experience with

  • Carboplatin
  • Paclitaxel
  • Olaparib
  • Pembrolizumab
  • Biospecimen Collection
  • Cediranib Maleate

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