Dr. Joseph C. Masdeu - Neurologist in ...

Dr. Joseph C Masdeu, MD, PhD

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Houston Methodist Neurological Institute

Studies Mild Cognitive Impairment
Studies Dementia
7 reported clinical trials
9 drugs studied

Affiliated Hospitals

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Houston Methodist Neurological Institute

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Houston Methodist Research Ins

Clinical Trials Joseph C Masdeu, MD, PhD is currently running

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Ocrelizumab

for Psychosis

Some people who have what doctors currently call schizophrenia or bipolar disease may actually have a brain disease caused by auto-antibodies. Auto-antibodies are produced when the normal defense mechanism of the body goes wrong and begins to attack the body, similar to "friendly fire." Auto-antibodies attack brain receptors and then the person who has this problem begins to have hallucinations and other manifestations of schizophrenia, like feeling that people can see what they are thinking and also feeling that other people do not like them. If this disease is caused by auto-antibodies, typically the person is well until they are 15 years of age or older, but seldom older than 35 years. Then, in a matter of a few months they begin to have hallucinations and the other symptoms. Doctors still do not know whether some people with schizophrenia or bipolar disease have auto-antibodies attacking their brain. For this reason, in this study some of these patients will receive a treatment that suppresses the auto-antibodies and their symptoms after treatment will be compared with the symptoms of a group of similar patients who are given a preparation that looks like the real treatment, but it is not.

Recruiting

1 award

Phase 1 & 2

5 criteria

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Research

for Frontotemporal Dementia

ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) represents the formalized integration of ARTFL (U54 NS092089; funded through 2019) and LEFFTDS (U01 AG045390; funded through 2019) as a single North American research consortium to study FTLD for 2019 and beyond.

Recruiting

1 award

N/A

10 criteria

More about Joseph C Masdeu, MD, PhD

Clinical Trial Related

8 years of experience running clinical trials · Led 7 trials as a Principal Investigator · 2 Active Clinical Trials

Treatments Joseph C Masdeu, MD, PhD has experience with

  • Ocrelizumab
  • Donanemab
  • Nicotine Transdermal Patch
  • Placebo Patch
  • Florbetaben
  • Flortaucipir

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