John A. Ellerton | Optum Care Cancer Care

Dr. John A. Ellerton

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OptumCare Cancer Care at Fort Apache

Expert in Breast Cancer
Expert in Lung Cancer
158 reported clinical trials
235 drugs studied

Area of expertise

1

Breast Cancer

Global Leader

John A. Ellerton has run 28 trials for Breast Cancer. Some of their research focus areas include:

Stage IV
HER2 positive
ER positive
2

Lung Cancer

Global Leader

John A. Ellerton has run 27 trials for Lung Cancer. Some of their research focus areas include:

Stage IV
Stage III
Stage II

Affiliated Hospitals

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OptumCare Cancer Care At Fort Apache

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OptumCare Cancer Care At Charleston

Clinical Trials John A. Ellerton is currently running

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Chemotherapy + Immunotherapy

for Esophageal and Gastric Cancer

This phase III trial compares the effect of modified fluorouracil, leucovorin calcium, oxaliplatin, and irinotecan (mFOLFIRINOX) with or without nivolumab to the effect of modified fluorouracil, leucovorin calcium, and oxaliplatin (mFOLFOX) with or without nivolumab for the treatment of patients with advanced, unresectable, or metastatic HER2 negative esophageal, gastroesophageal junction, or gastric adenocarcinoma. The usual approach for patients who are not in a study is treatment with FOLFOX with some receiving an immunotherapy drug, either nivolumab or pembrolizumab, in addition to FOLFOX chemotherapy. The usual approach is defined as care most people get for cancer in the stomach, esophagus, or gastroesophageal junction. Fluorouracil is in a class of medications called antimetabolites. It stops cells from making DNA and may kill tumor cells. Leucovorin in a class of medications called folic acid analogs. When used with fluorouracil it enhances the effects of this chemotherapy drug. Irinotecan is in a class of antineoplastic medications called topoisomerase I inhibitors. It blocks a certain enzyme needed for cell division and DNA repair, and may kill cancer cells. Oxaliplatin is in a class of medications called platinum-containing antineoplastic agents. It damages the cell's DNA and may kill cancer cells. Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer and may interfere with the ability of tumor cells to grow and spread. Some patients on this trial will receive nivolumab, in addition to mFOLFOX or mFOLFIRINOX chemotherapy. mFOLFIRINOX with or without nivolumab may be more effective than mFOLFOX with or without nivolumab by shrinking the tumor in patients with advanced, unresectable, or metastatic HER2-negative esophageal, gastroesophageal junction, or gastric adenocarcinoma.

Recruiting

2 awards

Phase 3

2 criteria

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Multiple Targeted Therapies

for Meningioma

This trial studies four drugs to treat patients with worsening meningioma. These drugs work by blocking enzymes that the tumor cells need to grow. The trial focuses on patients whose tumors have specific genetic mutations.

Recruiting

1 award

Phase 2

10 criteria

More about John A. Ellerton

Clinical Trial Related

7 years of experience running clinical trials · Led 158 trials as a Principal Investigator · 40 Active Clinical Trials

Treatments John A. Ellerton has experience with

  • Paclitaxel
  • Nivolumab
  • Carboplatin
  • Fluorouracil
  • Pembrolizumab
  • Cisplatin

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