Brian Van Tine, MD, PhD - Washington ...

Dr. Brian A Van Tine, M.D., Ph.D.

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Washington University School of Medicine

Expert in Soft Tissue Sarcoma
Expert in Cancer
49 reported clinical trials
67 drugs studied

About Brian A Van Tine, M.D., Ph.D.

Education:

  • Earned an M.D. from the University of Texas Southwestern Medical Center in 2000.
  • Obtained a Ph.D. in Cellular and Molecular Biology from the University of Texas Graduate School of Biomedical Sciences in 2000.

Experience:

  • Has been an Assistant Professor of Medicine at Washington University School of Medicine since 2009.
  • Serving as the Director of the Sarcoma Program at Siteman Cancer Center, Washington University School of Medicine, since 2015.

Area of expertise

1

Soft Tissue Sarcoma

Global Leader

Brian A Van Tine, M.D., Ph.D. has run 16 trials for Soft Tissue Sarcoma. Some of their research focus areas include:

Stage IV
Stage III
ALK positive
2

Cancer

Global Leader

Brian A Van Tine, M.D., Ph.D. has run 11 trials for Cancer. Some of their research focus areas include:

Stage IV
Stage III
ALK positive

Affiliated Hospitals

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Washington University School Of Medicine

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Washington University

Clinical Trials Brian A Van Tine, M.D., Ph.D. is currently running

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Circulating Tumor DNA

for Cancer

Earlier detection of disease recurrence will enable greater treatment options and has strong potential to improve patient outcomes. This project is translational and has the potential to lead to future translational research opportunities, including interventional trials in which therapeutic escalation is offered at the early circulating tumor DNA (ctDNA) molecular residual disease (MRD) detection timepoint. Ultimately, the integration of ctDNA into the clinical workflow has the potential to enhance cancer diagnosis, treatment, surveillance, and prognosis, and guide clinical decision-making in this era of personalized precision medicine.

Recruiting

1 award

N/A

1 criteria

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Registry

for Peripheral Nerve Sheath Tumor

First, the investigators plan to use a retrospective analysis to determine the clinical landscape of neurofibromatosis (NF)1-associated malignant peripheral nerve sheath tumor (MPNST) and precursor lesions (e.g., atypical or nodular plexiform neurofibromas). A worldwide database will be established, collecting, in a standardized manner, histologic, immunohistochemical, molecular, radiographic, treatment, and related clinical data from centers worldwide with expertise in these NF1-related cancers. Although retrospective in nature, the resulting data from this registry may reveal previously unanticipated patterns, similar to the INFACT effort outcome. This registry would then allow the acquisition of data associated with MPNST biospecimens collected under associated banks (frozen or paraffin-embedded, germline (or normal tissue DNA) samples, and any previously somatic whole-exome or whole-genome sequencing data for aggregate analyses). Second, the investigators plan to co-register patients to institutional banks in order to prospectively collect MPNST samples for analysis. These patients will be consented in order to collect the above information and for banking of tumor tissue and future studies that include genomic characterization of the tumors.

Recruiting

1 award

N/A

1 criteria

More about Brian A Van Tine, M.D., Ph.D.

Clinical Trial Related

4 years of experience running clinical trials · Led 49 trials as a Principal Investigator · 9 Active Clinical Trials

Treatments Brian A Van Tine, M.D., Ph.D. has experience with

  • Cyclophosphamide
  • Nivolumab
  • Placebo
  • Temozolomide
  • Pembrolizumab
  • Dacarbazine

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