Dr. Anthony Apicelli, M.D.
Claim this profileWashington University School of Medicine
Affiliated Hospitals
Washington University School Of Medicine
Clinical Trials Anthony Apicelli, M.D. is currently running
Proton Radiotherapy
for Palliative Cancer Care
Spatially fractionated radiotherapy (SFRT or GRID) addresses some limitations of traditional stereotactic body radiation therapy by relying on beam collimation to create high-dose "peaks" and intervening low-dose "valleys" throughout the target volume. Standard palliative radiotherapy regimens provide limited durability of response, and there are challenges with delivery to large tumors or in previously irradiated fields. In this study, Proton GRID radiotherapy will be used to deliver three-fraction palliative radiotherapy to patients with tumors needing palliative radiation. The safety and efficacy of this approach will be assessed. It is hypothesized that GRID is highly effective, immunogenic, and associated with low rates of toxicity.
Recruiting
1 award
N/A
Radiation, Cisplatin, and Surgery
for Throat Cancer
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer. Oropharynx SCC (OPSCC) is a common sub-type of HNSCC. Each year, 16,000 new cases of OPSCC are diagnosed in the USA. Most cases of OPSCC (\>90%) are caused by the human papillomavirus (HPV) and are often cured with current therapy. However, patients treated with surgery followed by postoperative adjuvant chemotherapy and radiation therapy (POA(C)RT) still experience substantial morbidity. In this highly curable disease, current clinical research interest is focused on investigation of de-escalated therapy, with the goal to reduce treatment-related adverse events (AEs) while maintaining a low recurrence rate. In this study, patients with HPV-related OPSCC will undergo resection of the primary tumor site and involved/at-risk regional neck nodes. Based on the pathology report, patients will be assigned to: * Arm 1 (de-POACRT-42 Gy) * Arm 2A (de-POART-42 Gy) * Arm 2B (de-POART-37.8 Gy) * Arm 2C (de-POACRT-30 Gy). All patients with high-risk pathology will be assigned to Arm 1 whereas patients with intermediate-risk pathology will be randomized (1:1:1) to Arm 2A, Arm 2B, or Arm 2C. Patients with highest-risk pathology and low-risk pathology will be removed from the trial after surgery and will be advised to pursue standard of care options.
Recruiting
1 award
Phase 2
6 criteria
More about Anthony Apicelli, M.D.
Clinical Trial Related
6 years of experience running clinical trials · Led 4 trials as a Principal Investigator · 2 Active Clinical Trials
Treatments Anthony Apicelli, M.D. has experience with
- Radiation Therapy
- Proton GRID Radiotherapy
- Paclitaxel
- Research Blood Draw
- ADI PEG20
- Ifosfamide
Breakdown of trials Anthony Apicelli, M.D. has run
Solid Tumors
Soft Tissue Sarcoma
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Anthony Apicelli, M.D. specialize in?
Anthony Apicelli, M.D. focuses on Cancer and Solid Tumors. In particular, much of their work with Cancer has involved Stage IV patients, or patients who are undergoing treatment.
Is Anthony Apicelli, M.D. currently recruiting for clinical trials?
Yes, Anthony Apicelli, M.D. is currently recruiting for 2 clinical trials in Saint Louis Missouri. If you're interested in participating, you should apply.
Are there any treatments that Anthony Apicelli, M.D. has studied deeply?
Yes, Anthony Apicelli, M.D. has studied treatments such as Radiation therapy, Proton GRID Radiotherapy, Paclitaxel.
What is the best way to schedule an appointment with Anthony Apicelli, M.D.?
Apply for one of the trials that Anthony Apicelli, M.D. is conducting.
What is the office address of Anthony Apicelli, M.D.?
The office of Anthony Apicelli, M.D. is located at: Washington University School of Medicine, Saint Louis, Missouri 63110 United States. This is the address for their practice at the Washington University School of Medicine.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.
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