Dr. Amitabh Chak, MD
Claim this profileUniversity Hospitals Cleveland Medical Center
Affiliated Hospitals
University Hospitals Cleveland Medical Center
University Hospitals Cleveland Medical Center, Seidman Cancer Center, Case Comprehensive Cancer Center
Clinical Trials Amitabh Chak, MD is currently running
Endoscopic Therapy vs Surveillance
for Barrett's Esophagus
The purpose of this study is to learn the best approach to treating patients with known or suspected Barrett's esophagus by comparing endoscopic surveillance to endoscopic eradication therapy. To diagnose and manage Barrett's esophagus and low-grade dysplasia, doctors commonly use procedures called endoscopic surveillance and endoscopic eradication therapy. Endoscopic surveillance is a type of procedure where a physician will run a tube with a light and a camera on the end of it down the patients throat and remove a small piece of tissue. The piece of tissue, called a biopsy, is about the size of the tip of a ball-point pen and is checked for abnormal cells and cancer cells. Endoscopic eradication therapy is a kind of surgery which is performed to destroy the precancerous cells at the bottom of the esophagus, so that healthy cells can grow in their place. It involves procedures to either remove precancerous tissue or burn it. These procedures can have side effects, so it is not certain whether risking those side effects is worth the benefit people get from the treatments. While both of these procedures are widely accepted approaches to managing the condition, there is not enough research to show if one is better than the other. Barrett's esophagus and low-grade dysplasia does not always worsen to high-grade dysplasia and/or cancer. In fact, it usually does not. So, if a patient's dysplasia is not worsening, doctors would rather not put patients at risk unnecessarily. On the other hand, endoscopic eradication therapy could possibly prevent the worsening of low-grade dysplasia into high-grade dysplasia or cancer (esophageal adenocarcinoma) in some patients. Researchers believe that the results of this study will help doctors choose the safest and most effective procedure for their patients with Barrett's esophagus and low-grade dysplasia. This is a multicenter study involving several academic, community and private hospitals around the United States. Up to 530 participants will be randomized. This study will also include a prospective observational cohort study of up to 150 Barrett's esophagus and low grade dysplasia patients who decline randomization in the randomized control trial but undergo endoscopic surveillance (Cohort 1) or endoscopic eradication therapy (Cohort 2), and are willing to provide longitudinal observational data.
Recruiting
1 award
N/A
Itraconazole + Ablation
for Preventing Esophageal Cancer
This phase II trial tests how well itraconazole works in combination with the usual standard of care endoscopy with ablation for the prevention of esophageal cancer in patients who have high-risk Barrett's esophagus (BE). BE is a condition in which the lining of the esophagus changes and becomes more like the tissue that lines the intestine. People with Barrett's esophagus have a higher risk of developing esophageal cancer. Itraconazole is a drug used to prevent or treat fungal infections. Ablation refers to the removal of abnormal tissue using heat. Endoscopy is a procedure for looking at the esophagus using a long, flexible tube called an endoscope, which has a video camera at the end. Radiofrequency ablation is a type of heat therapy that uses radiofrequency energy (similar to microwave heat) to destroy the abnormal tissue in the esophagus. Giving itraconazole in combination with standard of care endoscopy with ablation may improve the effects of ablation and prevent esophageal cancer in patients with high-risk Barrett's esophagus.
Recruiting
0 awards
Phase 2
5 criteria
More about Amitabh Chak, MD
Clinical Trial Related
3 years of experience running clinical trials · Led 9 trials as a Principal Investigator · 6 Active Clinical Trials
Treatments Amitabh Chak, MD has experience with
- EsoCheck/EsoGuard (EC/EG)
- Esophago-gastro-duodenoscopy (EGD)
- EsoCheck
- EsoGuard
- Obeticholic Acid
- Endoscopy
Breakdown of trials Amitabh Chak, MD has run
Barrett's Esophagus
Esophageal Physiopathology
Esophageal Cancer
Esophageal Adenocarcinoma
Gastroesophageal Reflux Disease
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Amitabh Chak, MD specialize in?
Amitabh Chak, MD focuses on Barrett's Esophagus and Esophageal Physiopathology. In particular, much of their work with Barrett's Esophagus has involved treating patients, or patients who are undergoing treatment.
Is Amitabh Chak, MD currently recruiting for clinical trials?
Yes, Amitabh Chak, MD is currently recruiting for 6 clinical trials in Cleveland Ohio. If you're interested in participating, you should apply.
Are there any treatments that Amitabh Chak, MD has studied deeply?
Yes, Amitabh Chak, MD has studied treatments such as EsoCheck/EsoGuard (EC/EG), Esophago-gastro-duodenoscopy (EGD), EsoCheck.
What is the best way to schedule an appointment with Amitabh Chak, MD?
Apply for one of the trials that Amitabh Chak, MD is conducting.
What is the office address of Amitabh Chak, MD?
The office of Amitabh Chak, MD is located at: University Hospitals Cleveland Medical Center, Cleveland, Ohio 44106 United States. This is the address for their practice at the University Hospitals Cleveland Medical Center.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.
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