Alexander Drilon, MD - MSK Thoracic ...

Dr. Alexander Drilon, MD

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Memorial Sloan Kettering Cancer Center

Studies Non-Small Cell Lung Cancer
Studies Solid Tumors
11 reported clinical trials
13 drugs studied

Area of expertise

1

Non-Small Cell Lung Cancer

Alexander Drilon, MD has run 6 trials for Non-Small Cell Lung Cancer. Some of their research focus areas include:

RET positive
Stage IV
Stage III
2

Solid Tumors

Alexander Drilon, MD has run 6 trials for Solid Tumors. Some of their research focus areas include:

Stage IV
Stage III
ALK positive

Affiliated Hospitals

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Memorial Sloan Kettering Cancer Center

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Memorial Sloan Kettering Cancer Center PHASE 1 (recruiting) & PHASE 2 (Recruiting)

Clinical Trials Alexander Drilon, MD is currently running

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NVL-655

for NSCLC

This trial is testing a new drug called NVL-655 to see if it is safe and effective for patients with advanced ALK-positive lung cancer and other solid tumors. The drug works by blocking a protein that helps cancer cells grow. The study focuses on patients who have specific genetic changes and may not respond well to standard treatments. Newer treatments have been shown to improve outcomes in ALK-translocated lung cancer compared to older treatments.

Recruiting

1 award

Phase 1 & 2

7 criteria

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Repotrectinib

for Solid Tumors

Phase 1 dose escalation will determine the first cycle dose-limiting toxicities (DLTs), the maximum tolerated dose (MTD), the biologically effective dose and recommended Phase 2 dose (RP2D) of repotrectinib given to adult subjects with advanced solid malignancies harboring an ALK, ROS1, NTRK1, NTRK2, or NTRK3 gene rearrangement. Midazolam DDI substudy will examine effect of of repotrectinib on CYP3A induction. Phase 2 will determine the confirmed Overall Response Rate (ORR) as assessed by Blinded Independent Central Review (BICR) of repotrectinib in each subject population expansion cohort of advanced solid tumors that harbor a ROS1, NTRK1, NTRK2, or NTRK3 gene rearrangement. The secondary objective will include the duration of response (DOR), time to response (TTR), progression-free survival (PFS), overall survival (OS) and clinical benefit rate (CBR) of repotrectinib in each expansion cohort of advanced solid tumors that harbor a ROS1, NTRK1, NTRK2, or NTRK3 gene rearrangement.

Recruiting

1 award

Phase 1 & 2

7 criteria

More about Alexander Drilon, MD

Clinical Trial Related

4 years of experience running clinical trials · Led 11 trials as a Principal Investigator · 4 Active Clinical Trials

Treatments Alexander Drilon, MD has experience with

  • Cabozantinib
  • Repotrectinib (TPX-0005)
  • ELU001
  • TPX-0046
  • NVL-655
  • NVL-520

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